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Molecules 2012, 17(6), 6348-6361; doi:10.3390/molecules17066348

Article

Zinc Phthalocyanine Labelled Polyethylene Glycol: Preparation, Characterization, Interaction with Bovine Serum Albumin and Near Infrared Fluorescence Imaging in Vivo

Feng Lv, Bo Cao, Yanli Cui and Tianjun Liu*

Tianjin Key Laboratory of Biomedical Materials, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300192, China

* Author to whom correspondence should be addressed.

Received: 27 April 2012; in revised form: 16 May 2012 / Accepted: 17 May 2012 / Published: 25 May 2012

(This article belongs to the Special Issue Tetrapyrroles, Porphyrins and Phthalocyanine)

Download PDF Full-Text [1310 KB, uploaded 25 May 2012 15:22 CEST]

Abstract: Zinc phthalocyanine labelled polyethylene glycol was prepared to track and monitor the in vivo fate of polyethylene glycol. The chemical structures were characterized by nuclear magnetic resonance and infrared spectroscopy. Their light stability and fluorescence quantum yield were evaluated by UV-Visible and fluorescence spectroscopy methods. The interaction of zinc phthalocyanine labelled polyethylene glycol with bovine serum albumin was evaluated by fluorescence titration and isothermal titration calorimetry methods. Optical imaging in vivo, organ aggregation as well as distribution of fluorescence experiments for tracking polyethylene glycol were performed with zinc phthalocyanine labelled polyethylene glycol as fluorescent agent. Results show that zinc phthalocyanine labelled polyethylene glycol has good optical stability and high emission ability in the near infrared region. Imaging results demonstrate that zinc phthalocyanine labelled polyethylene glycol can track and monitor the in vivo process by near infrared fluorescence imaging, which implies its potential in biomaterials evaluation in vivo by a real-time noninvasive method.

Keywords: zinc phthalocyanine; polyethylene glycol; near infrared fluorescence imaging

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