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Biocatalytic Resolution of Enantiomeric Mixtures of 1-Aminoethanephosphonic Acid
Department of Bioorganic Chemistry, Faculty of Chemistry, Wroclaw University of Technology, Wybrzeże Wyspiańskiego 27, 50-370 Wroclaw, Poland
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Received: 29 June 2011; in revised form: 12 July 2011 / Accepted: 12 July 2011 / Published: 14 July 2011
Abstract: Several fungal strains, namely Bauveria bassiana, Cuninghamella echinulata, Aspergillus fumigatus, Penicillium crustosum and Cladosporium herbarum, were used as biocatalysts to resolve racemic mixtures of 1-aminoethanephosphonic acid using L/D amino acid oxidase activity. The course of reaction was analyzed by 31P-NMR in the presence of cyclodextrin used as chiral discriminating agent. The best result (42% e.e of R-isomer) was obtained with a strain of Cuninghamella echinulata.
Keywords: aminophosphonic acid; fungi; resolution of racemic mixture
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Brzezińska-Rodak, M.; Klimek-Ochab, M.; Żymańczyk-Duda, E.; Kafarski, P. Biocatalytic Resolution of Enantiomeric Mixtures of 1-Aminoethanephosphonic Acid. Molecules 2011, 16, 5896-5904.
Brzezińska-Rodak M, Klimek-Ochab M, Żymańczyk-Duda E, Kafarski P. Biocatalytic Resolution of Enantiomeric Mixtures of 1-Aminoethanephosphonic Acid. Molecules. 2011; 16(7):5896-5904.
Brzezińska-Rodak, Małgorzata; Klimek-Ochab, Magdalena; Żymańczyk-Duda, Ewa; Kafarski, Paweł. 2011. "Biocatalytic Resolution of Enantiomeric Mixtures of 1-Aminoethanephosphonic Acid." Molecules 16, no. 7: 5896-5904.