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On the Reducible Character of Haldane-Radić Enzyme Kinetics to Conventional and Logistic Michaelis-Menten Models
Molecules 2011, 16(7), 5896-5904; doi:10.3390/molecules16075896

Biocatalytic Resolution of Enantiomeric Mixtures of 1-Aminoethanephosphonic Acid

* , ,  and
Department of Bioorganic Chemistry, Faculty of Chemistry, Wroclaw University of Technology, Wybrzeże Wyspiańskiego 27, 50-370 Wroclaw, Poland
* Author to whom correspondence should be addressed.
Received: 29 June 2011 / Revised: 12 July 2011 / Accepted: 12 July 2011 / Published: 14 July 2011
(This article belongs to the Special Issue Enzyme-Catalyzed Reactions)
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Several fungal strains, namely Bauveria bassiana, Cuninghamella echinulata, Aspergillus fumigatus, Penicillium crustosum and Cladosporium herbarum, were used as biocatalysts to resolve racemic mixtures of 1-aminoethanephosphonic acid using L/D amino acid oxidase activity. The course of reaction was analyzed by 31P-NMR in the presence of cyclodextrin used as chiral discriminating agent. The best result (42% e.e of R-isomer) was obtained with a strain of Cuninghamella echinulata.
Keywords: aminophosphonic acid; fungi; resolution of racemic mixture aminophosphonic acid; fungi; resolution of racemic mixture
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Brzezińska-Rodak, M.; Klimek-Ochab, M.; Żymańczyk-Duda, E.; Kafarski, P. Biocatalytic Resolution of Enantiomeric Mixtures of 1-Aminoethanephosphonic Acid. Molecules 2011, 16, 5896-5904.

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