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Molecules 2011, 16(7), 5896-5904; doi:10.3390/molecules16075896

Biocatalytic Resolution of Enantiomeric Mixtures of 1-Aminoethanephosphonic Acid

Department of Bioorganic Chemistry, Faculty of Chemistry, Wroclaw University of Technology, Wybrzeże Wyspiańskiego 27, 50-370 Wroclaw, Poland
Author to whom correspondence should be addressed.
Received: 29 June 2011 / Revised: 12 July 2011 / Accepted: 12 July 2011 / Published: 14 July 2011
(This article belongs to the Special Issue Enzyme-Catalyzed Reactions)
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Several fungal strains, namely Bauveria bassiana, Cuninghamella echinulata, Aspergillus fumigatus, Penicillium crustosum and Cladosporium herbarum, were used as biocatalysts to resolve racemic mixtures of 1-aminoethanephosphonic acid using L/D amino acid oxidase activity. The course of reaction was analyzed by 31P-NMR in the presence of cyclodextrin used as chiral discriminating agent. The best result (42% e.e of R-isomer) was obtained with a strain of Cuninghamella echinulata.
Keywords: aminophosphonic acid; fungi; resolution of racemic mixture aminophosphonic acid; fungi; resolution of racemic mixture
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Brzezińska-Rodak, M.; Klimek-Ochab, M.; Żymańczyk-Duda, E.; Kafarski, P. Biocatalytic Resolution of Enantiomeric Mixtures of 1-Aminoethanephosphonic Acid. Molecules 2011, 16, 5896-5904.

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