Molecules 2011, 16(4), 3128-3145; doi:10.3390/molecules16043128
Article

On the Reducible Character of Haldane-Radić Enzyme Kinetics to Conventional and Logistic Michaelis-Menten Models

email
Received: 11 March 2011; in revised form: 13 April 2011 / Accepted: 13 April 2011 / Published: 13 April 2011
(This article belongs to the Special Issue Enzyme-Catalyzed Reactions)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: The conceptual and practical issues regarding the reduction of the Haldane-Radić enzymic mechanism, specific for cholinesterase kinetics, to the consecrated or logistically modified Michaelis-Menten kinetics, specific for some mutant enzymes, are here clarified as due to the limited initial substrate concentration, through detailed initial rate and progress curve analysis, even when other classical conditions for such equivalence are not entirely fulfilled.
Keywords: W-Lambert equation; logistic transformation; cholinesterases; fitting curves; kinetic parameters
PDF Full-text Download PDF Full-Text [423 KB, uploaded 18 June 2014 19:37 CEST]

Export to BibTeX |
EndNote


MDPI and ACS Style

Putz, M.V. On the Reducible Character of Haldane-Radić Enzyme Kinetics to Conventional and Logistic Michaelis-Menten Models. Molecules 2011, 16, 3128-3145.

AMA Style

Putz MV. On the Reducible Character of Haldane-Radić Enzyme Kinetics to Conventional and Logistic Michaelis-Menten Models. Molecules. 2011; 16(4):3128-3145.

Chicago/Turabian Style

Putz, Mihai V. 2011. "On the Reducible Character of Haldane-Radić Enzyme Kinetics to Conventional and Logistic Michaelis-Menten Models." Molecules 16, no. 4: 3128-3145.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert