Molecules 2011, 16(4), 3128-3145; doi:10.3390/molecules16043128
Article

On the Reducible Character of Haldane-Radić Enzyme Kinetics to Conventional and Logistic Michaelis-Menten Models

Mihai V. Putzemail
Laboratory of Computational and Structural Physical Chemistry, Chemistry Department, West University of Timişoara, Pestalozzi Street No.16, Timisoara, RO-300115, Romania
Received: 11 March 2011; in revised form: 13 April 2011 / Accepted: 13 April 2011 / Published: 13 April 2011
(This article belongs to the Special Issue Enzyme-Catalyzed Reactions)
PDF Full-text Download PDF Full-Text [423 KB, uploaded 13 April 2011 14:10 CEST]
Abstract: The conceptual and practical issues regarding the reduction of the Haldane-Radić enzymic mechanism, specific for cholinesterase kinetics, to the consecrated or logistically modified Michaelis-Menten kinetics, specific for some mutant enzymes, are here clarified as due to the limited initial substrate concentration, through detailed initial rate and progress curve analysis, even when other classical conditions for such equivalence are not entirely fulfilled.
Keywords: W-Lambert equation; logistic transformation; cholinesterases; fitting curves; kinetic parameters

Article Statistics

Click here to load and display the download statistics.

Cite This Article

MDPI and ACS Style

Putz, M.V. On the Reducible Character of Haldane-Radić Enzyme Kinetics to Conventional and Logistic Michaelis-Menten Models. Molecules 2011, 16, 3128-3145.

AMA Style

Putz MV. On the Reducible Character of Haldane-Radić Enzyme Kinetics to Conventional and Logistic Michaelis-Menten Models. Molecules. 2011; 16(4):3128-3145.

Chicago/Turabian Style

Putz, Mihai V. 2011. "On the Reducible Character of Haldane-Radić Enzyme Kinetics to Conventional and Logistic Michaelis-Menten Models." Molecules 16, no. 4: 3128-3145.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert