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Molecules 2011, 16(4), 3119-3127; doi:10.3390/molecules16043119

Lancifoliaine, a New Bisbenzylisoquinoline from the Bark of Litsea lancifolia

1,* , 1
3 and 3
1 Centre for Natural Products and Drug Discovery, Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia 2 Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS, 1, Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France 3 Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa-ku, Tokyo 142-8501, Japan
* Author to whom correspondence should be addressed.
Received: 7 January 2011 / Revised: 5 April 2011 / Accepted: 11 April 2011 / Published: 13 April 2011
(This article belongs to the Section Natural Products)
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A new bisbenzylisoquinoline, lancifoliaine (1), together with seven known alkaloids – N-allyllaurolitsine (2), reticuline (3), actinodaphnine, norboldine, pallidine, cassythicine and boldine – were isolated from the stem bark of Litsea lancifolia (Lauraceae). In addition to that of lancifoliaine, complete 13C-NMR data of N-allyl-laurolitsine (2) was also reported. The alkaloidal structures were elucidated by means of high field 1D- and 2D-NMR IR, UV, and LCMS-IT-TOF spectral data. N-Allyllaurolitsine (2) showed a moderate vasorelaxant activity on isolated rat aorta.
Keywords: bisbenzylisoquinoline; lancifoliaine; N-allyllaurolitsine; Lauraceae; vaso-relaxant activity bisbenzylisoquinoline; lancifoliaine; N-allyllaurolitsine; Lauraceae; vaso-relaxant activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Sulaiman, S.N.; Mukhtar, M.R.; Hadi, A.H.A.; Awang, K.; Hazni, H.; Zahari, A.; Litaudon, M.; Zaima, K.; Morita, H. Lancifoliaine, a New Bisbenzylisoquinoline from the Bark of Litsea lancifolia. Molecules 2011, 16, 3119-3127.

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