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Molecules 2011, 16(4), 3119-3127; doi:10.3390/molecules16043119

Lancifoliaine, a New Bisbenzylisoquinoline from the Bark of Litsea lancifolia

1,* , 1
3 and 3
1 Centre for Natural Products and Drug Discovery, Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia 2 Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS, 1, Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France 3 Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa-ku, Tokyo 142-8501, Japan
* Author to whom correspondence should be addressed.
Received: 7 January 2011 / Revised: 5 April 2011 / Accepted: 11 April 2011 / Published: 13 April 2011
(This article belongs to the Section Natural Products)
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A new bisbenzylisoquinoline, lancifoliaine (1), together with seven known alkaloids – N-allyllaurolitsine (2), reticuline (3), actinodaphnine, norboldine, pallidine, cassythicine and boldine – were isolated from the stem bark of Litsea lancifolia (Lauraceae). In addition to that of lancifoliaine, complete 13C-NMR data of N-allyl-laurolitsine (2) was also reported. The alkaloidal structures were elucidated by means of high field 1D- and 2D-NMR IR, UV, and LCMS-IT-TOF spectral data. N-Allyllaurolitsine (2) showed a moderate vasorelaxant activity on isolated rat aorta.
Keywords: bisbenzylisoquinoline; lancifoliaine; N-allyllaurolitsine; Lauraceae; vaso-relaxant activity bisbenzylisoquinoline; lancifoliaine; N-allyllaurolitsine; Lauraceae; vaso-relaxant activity
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Sulaiman, S.N.; Mukhtar, M.R.; Hadi, A.H.A.; Awang, K.; Hazni, H.; Zahari, A.; Litaudon, M.; Zaima, K.; Morita, H. Lancifoliaine, a New Bisbenzylisoquinoline from the Bark of Litsea lancifolia. Molecules 2011, 16, 3119-3127.

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