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Molecules 2011, 16(4), 3146-3151; doi:10.3390/molecules16043146

Screening for Compounds with Aromatase Inhibiting Activities from Atractylodes macrocephala Koidz

2,*  and 2
1 Department of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University, No.79 Qingchun Rd., Hangzhou 310003, China 2 Department of Pharmacy, Zhejiang Medical College, No.481 Binwen Rd., Hangzhou 310053, China
* Author to whom correspondence should be addressed.
Received: 31 March 2011 / Revised: 11 April 2011 / Accepted: 12 April 2011 / Published: 14 April 2011
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Ten compounds were isolated from the dichloromethane extract of Atractylodes macrocephala and their aromatase inhibiting activities were tested using an in vitro fluorescent-based aromatase assay. The results indicated that atractylenolide I (1), atractylenolide II (2) and atractylenolide III (3) had inhibition ratios of 94.56 ± 0.70%, 90.93 ± 1.41% and 86.31 ± 8.46%, respectively, at a concentration of 10 μM. We conclude from our results that atractylenolide and its derivates may serve as potential aromatase inhibitors (AIs) and thus merit continued study in the future.
Keywords: aromatase; Atractylodes macrocephala; atractylenolide aromatase; Atractylodes macrocephala; atractylenolide
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Jiang, H.; Shi, J.; Li, Y. Screening for Compounds with Aromatase Inhibiting Activities from Atractylodes macrocephala Koidz. Molecules 2011, 16, 3146-3151.

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