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• Jiang, H
• Shi, J
• Li, Y
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• Shi, J
• Li, Y
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• Shi, J
• Li, Y

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Molecules 2011, 16(4), 3146-3151; doi:10.3390/molecules16043146

Communication

Screening for Compounds with Aromatase Inhibiting Activities from Atractylodes macrocephala Koidz

Hai Jiang ¹ , Jing Shi ^2,*  and Yuanyuan Li ²

¹ Department of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University, No.79 Qingchun Rd., Hangzhou 310003, China ² Department of Pharmacy, Zhejiang Medical College, No.481 Binwen Rd., Hangzhou 310053, China

* Author to whom correspondence should be addressed.

Received: 31 March 2011; in revised form: 11 April 2011 / Accepted: 12 April 2011 / Published: 14 April 2011

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Abstract: Ten compounds were isolated from the dichloromethane extract of Atractylodes macrocephala and their aromatase inhibiting activities were tested using an in vitro fluorescent-based aromatase assay. The results indicated that atractylenolide I (1), atractylenolide II (2) and atractylenolide III (3) had inhibition ratios of 94.56 ± 0.70%, 90.93 ± 1.41% and 86.31 ± 8.46%, respectively, at a concentration of 10 μM. We conclude from our results that atractylenolide and its derivates may serve as potential aromatase inhibitors (AIs) and thus merit continued study in the future.

Keywords: aromatase; Atractylodes macrocephala; atractylenolide

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