Molecules 2011, 16(4), 3146-3151; doi:10.3390/molecules16043146
Communication

Screening for Compounds with Aromatase Inhibiting Activities from Atractylodes macrocephala Koidz

1 Department of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University, No.79 Qingchun Rd., Hangzhou 310003, China 2 Department of Pharmacy, Zhejiang Medical College, No.481 Binwen Rd., Hangzhou 310053, China
* Author to whom correspondence should be addressed.
Received: 31 March 2011; in revised form: 11 April 2011 / Accepted: 12 April 2011 / Published: 14 April 2011
PDF Full-text Download PDF Full-Text [270 KB, Updated Version, uploaded 15 April 2011 08:53 CEST]
The original version is still available [270 KB, uploaded 14 April 2011 12:52 CEST]
Abstract: Ten compounds were isolated from the dichloromethane extract of Atractylodes macrocephala and their aromatase inhibiting activities were tested using an in vitro fluorescent-based aromatase assay. The results indicated that atractylenolide I (1), atractylenolide II (2) and atractylenolide III (3) had inhibition ratios of 94.56 ± 0.70%, 90.93 ± 1.41% and 86.31 ± 8.46%, respectively, at a concentration of 10 μM. We conclude from our results that atractylenolide and its derivates may serve as potential aromatase inhibitors (AIs) and thus merit continued study in the future.
Keywords: aromatase; Atractylodes macrocephala; atractylenolide

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Jiang, H.; Shi, J.; Li, Y. Screening for Compounds with Aromatase Inhibiting Activities from Atractylodes macrocephala Koidz. Molecules 2011, 16, 3146-3151.

AMA Style

Jiang H, Shi J, Li Y. Screening for Compounds with Aromatase Inhibiting Activities from Atractylodes macrocephala Koidz. Molecules. 2011; 16(4):3146-3151.

Chicago/Turabian Style

Jiang, Hai; Shi, Jing; Li, Yuanyuan. 2011. "Screening for Compounds with Aromatase Inhibiting Activities from Atractylodes macrocephala Koidz." Molecules 16, no. 4: 3146-3151.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert