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The Ups and Downs of Tannins as Inhibitors of Poly(ADP-Ribose)glycohydrolase
Institute of Pharmacology and Toxicology, University of Zurich-Vetsuisse, Winterthurerstrasse 260, 8057 Zurich, Switzerland
These authors contributed equally to this work.
* Author to whom correspondence should be addressed.
Received: 24 January 2011 / Accepted: 17 February 2011 / Published: 22 February 2011
(This article belongs to the Special Issue Tannins
Abstract: DNA damage to cells activates nuclear poly(ADP-ribose)polymerases (PARPs) and the poly(ADP-ribose) (PAR) synthesized is rapidly cleaved into ADP-ribose (ADPR) by PAR glycohydrolase (PARG) action. Naturally appearing tannin-like molecules have been implicated in specific inhibition of the PARG enzyme. This review deals with the in vitro and in vivo effects of tannins on PAR metabolism and their downstream actions in DNA damage signaling.
Keywords: tannin; gallotannin; tannic acid; PARG; poly(ADP-ribose)
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Cite This Article
MDPI and ACS Style
Blenn, C.; Wyrsch, P.; Althaus, F.R. The Ups and Downs of Tannins as Inhibitors of Poly(ADP-Ribose)glycohydrolase. Molecules 2011, 16, 1854-1877.
Blenn C, Wyrsch P, Althaus FR. The Ups and Downs of Tannins as Inhibitors of Poly(ADP-Ribose)glycohydrolase. Molecules. 2011; 16(2):1854-1877.
Blenn, Christian; Wyrsch, Philippe; Althaus, Felix R. 2011. "The Ups and Downs of Tannins as Inhibitors of Poly(ADP-Ribose)glycohydrolase." Molecules 16, no. 2: 1854-1877.