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Molecules 2011, 16(2), 1854-1877; doi:10.3390/molecules16021854

The Ups and Downs of Tannins as Inhibitors of Poly(ADP-Ribose)glycohydrolase

Institute of Pharmacology and Toxicology, University of Zurich-Vetsuisse, Winterthurerstrasse 260, 8057 Zurich, Switzerland
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 24 January 2011 / Accepted: 17 February 2011 / Published: 22 February 2011
(This article belongs to the Special Issue Tannins)
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Abstract

DNA damage to cells activates nuclear poly(ADP-ribose)polymerases (PARPs) and the poly(ADP-ribose) (PAR) synthesized is rapidly cleaved into ADP-ribose (ADPR) by PAR glycohydrolase (PARG) action. Naturally appearing tannin-like molecules have been implicated in specific inhibition of the PARG enzyme. This review deals with the in vitro and in vivo effects of tannins on PAR metabolism and their downstream actions in DNA damage signaling.
Keywords: tannin; gallotannin; tannic acid; PARG; poly(ADP-ribose) tannin; gallotannin; tannic acid; PARG; poly(ADP-ribose)
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Blenn, C.; Wyrsch, P.; Althaus, F.R. The Ups and Downs of Tannins as Inhibitors of Poly(ADP-Ribose)glycohydrolase. Molecules 2011, 16, 1854-1877.

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