Next Article in Journal
Enaminones as Building Blocks for the Synthesis of Substituted Pyrazoles with Antitumor and Antimicrobial Activities
Previous Article in Journal
New Chiral P-N Ligands for the Regio- and Stereoselective Pd-Catalyzed Dimerization of Styrene
Molecules 2011, 16(2), 1825-1833; doi:10.3390/molecules16021825
Article

Antileishmanial Activity of the Hydroalcoholic Extract of Miconia langsdorffii, Isolated Compounds, and Semi-Synthetic Derivatives

1
,
1
,
1
,
1
,
2
,
1
,
3
,
1
,
1
,
4
,
5
 and
1,*
Received: 8 February 2011 / Revised: 14 February 2011 / Accepted: 21 February 2011 / Published: 22 February 2011
(This article belongs to the Section Metabolites)
Download PDF [123 KB, uploaded 18 June 2014]

Abstract

The in vitro activity of the crude hydroalcoholic extract of the aerial parts of Miconia langsdorffii Cogn. was evaluated against the promastigote forms of L. amazonensis, the causative agent of cutaneous leishmaniasis in humans. The bioassay-guided fractionation of this extract led to identification of the triterpenes ursolic acid and oleanolic acid as the major compounds in the fraction that displayed the highest activity. Several ursolic acid semi-synthetic derivatives were prepared, to find out whether more active compounds could be obtained. Among these ursolic acid-derived substances, the C-28 methyl ester derivative exhibited the best antileishmanial activity.
Keywords: antileishmanial activity; Miconia langsdorffii; oleanolic acid; ursolic acid antileishmanial activity; Miconia langsdorffii; oleanolic acid; ursolic acid
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Share & Cite This Article

Further Mendeley | CiteULike
Export to BibTeX |
EndNote
MDPI and ACS Style

Peixoto, J.A.; Andrade e Silva, M.L.; Crotti, A.E.M.; Cassio Sola Veneziani, R.; Gimenez, V.M.M.; Januário, A.H.; Groppo, M.; Magalhães, L.G.; Dos Santos, F.F.; Albuquerque, S.; Da Silva Filho, A.A.; Cunha, W.R. Antileishmanial Activity of the Hydroalcoholic Extract of Miconia langsdorffii, Isolated Compounds, and Semi-Synthetic Derivatives. Molecules 2011, 16, 1825-1833.

View more citation formats

Related Articles

Article Metrics

For more information on the journal, click here

Comments

Cited By

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert