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Molecules 2011, 16(2), 1825-1833; doi:10.3390/molecules16021825
Article

Antileishmanial Activity of the Hydroalcoholic Extract of Miconia langsdorffii, Isolated Compounds, and Semi-Synthetic Derivatives

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Received: 8 February 2011; in revised form: 14 February 2011 / Accepted: 21 February 2011 / Published: 22 February 2011
(This article belongs to the Section Metabolites)
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Abstract: The in vitro activity of the crude hydroalcoholic extract of the aerial parts of Miconia langsdorffii Cogn. was evaluated against the promastigote forms of L. amazonensis, the causative agent of cutaneous leishmaniasis in humans. The bioassay-guided fractionation of this extract led to identification of the triterpenes ursolic acid and oleanolic acid as the major compounds in the fraction that displayed the highest activity. Several ursolic acid semi-synthetic derivatives were prepared, to find out whether more active compounds could be obtained. Among these ursolic acid-derived substances, the C-28 methyl ester derivative exhibited the best antileishmanial activity.
Keywords: antileishmanial activity; Miconia langsdorffii; oleanolic acid; ursolic acid antileishmanial activity; Miconia langsdorffii; oleanolic acid; ursolic acid
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Peixoto, J.A.; Andrade e Silva, M.L.; Crotti, A.E.M.; Cassio Sola Veneziani, R.; Gimenez, V.M.M.; Januário, A.H.; Groppo, M.; Magalhães, L.G.; Dos Santos, F.F.; Albuquerque, S.; Da Silva Filho, A.A.; Cunha, W.R. Antileishmanial Activity of the Hydroalcoholic Extract of Miconia langsdorffii, Isolated Compounds, and Semi-Synthetic Derivatives. Molecules 2011, 16, 1825-1833.

AMA Style

Peixoto JA, Andrade e Silva ML, Crotti AEM, Cassio Sola Veneziani R, Gimenez VMM, Januário AH, Groppo M, Magalhães LG, Dos Santos FF, Albuquerque S, Da Silva Filho AA, Cunha WR. Antileishmanial Activity of the Hydroalcoholic Extract of Miconia langsdorffii, Isolated Compounds, and Semi-Synthetic Derivatives. Molecules. 2011; 16(2):1825-1833.

Chicago/Turabian Style

Peixoto, Juliana A.; Andrade e Silva, Márcio Luis; Crotti, Antônio E. M.; Cassio Sola Veneziani, Rodrigo; Gimenez, Valéria M. M.; Januário, Ana H.; Groppo, Milton; Magalhães, Lizandra G.; Dos Santos, Fransérgio F.; Albuquerque, Sérgio; Da Silva Filho, Ademar A.; Cunha, Wilson R. 2011. "Antileishmanial Activity of the Hydroalcoholic Extract of Miconia langsdorffii, Isolated Compounds, and Semi-Synthetic Derivatives." Molecules 16, no. 2: 1825-1833.


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