Next Article in Journal
Enaminones as Building Blocks for the Synthesis of Substituted Pyrazoles with Antitumor and Antimicrobial Activities
Previous Article in Journal
New Chiral P-N Ligands for the Regio- and Stereoselective Pd-Catalyzed Dimerization of Styrene
Article Menu

Article Versions

Export Article

Open AccessArticle
Molecules 2011, 16(2), 1825-1833; doi:10.3390/molecules16021825

Antileishmanial Activity of the Hydroalcoholic Extract of Miconia langsdorffii, Isolated Compounds, and Semi-Synthetic Derivatives

1
Núcleo de Pesquisa em Ciências Exatas e Tecnológicas da Universidade de Franca, Av. Dr. Armando Salles de Oliveira 201 - Parque Universitário, CEP 14404-600, Franca, SP, Brazil
2
Centro Universitário Claretiano, Rua Dom Bosco 466, CEP 14300-000, Batatais, SP, Brazil
3
Departamento de Biologia, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Av. do Café s/n CEP 14040-901 Ribeirão Preto, SP, Brazil
4
Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Av. do Café s/n, CEP 14040-903, Ribeirão Preto, SP, Brazil
5
Departamento Farmacêutico, Universidade Federal de Juiz de Fora, Rua José Lourenço Kelmer s/n, Campus Universitário, CEP 36036-900, Juiz de Fora, MG, Brazil
*
Author to whom correspondence should be addressed.
Received: 8 February 2011 / Revised: 14 February 2011 / Accepted: 21 February 2011 / Published: 22 February 2011
(This article belongs to the Section Natural Products)
Download PDF [123 KB, uploaded 18 June 2014]

Abstract

The in vitro activity of the crude hydroalcoholic extract of the aerial parts of Miconia langsdorffii Cogn. was evaluated against the promastigote forms of L. amazonensis, the causative agent of cutaneous leishmaniasis in humans. The bioassay-guided fractionation of this extract led to identification of the triterpenes ursolic acid and oleanolic acid as the major compounds in the fraction that displayed the highest activity. Several ursolic acid semi-synthetic derivatives were prepared, to find out whether more active compounds could be obtained. Among these ursolic acid-derived substances, the C-28 methyl ester derivative exhibited the best antileishmanial activity.
Keywords: antileishmanial activity; Miconia langsdorffii; oleanolic acid; ursolic acid antileishmanial activity; Miconia langsdorffii; oleanolic acid; ursolic acid
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Peixoto, J.A.; Andrade e Silva, M.L.; Crotti, A.E.M.; Cassio Sola Veneziani, R.; Gimenez, V.M.M.; Januário, A.H.; Groppo, M.; Magalhães, L.G.; Dos Santos, F.F.; Albuquerque, S.; Da Silva Filho, A.A.; Cunha, W.R. Antileishmanial Activity of the Hydroalcoholic Extract of Miconia langsdorffii, Isolated Compounds, and Semi-Synthetic Derivatives. Molecules 2011, 16, 1825-1833.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top