Molecular Recognition Studies on Naphthyridine Derivatives
AbstractThe association constants Kb of three hosts I–III designed to have both enhanced hydrogen bonding donor strength and conformational preorganization with biotin analogues 1–5 are reported. 1H-NMR titrations under two different concentration conditions have been employed to determine the association constants Kb. A statistical analysis using a presence absence matrix has been applied to calculate the different contributions. Hydrogen bond interactions make naphthyridine derivatives II and III potent binders and effective receptors for (+)-biotin methyl ester (1), due to the complex stabilization by additional hydrogen bonds.
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Iglesias-Sánchez, J.C.; María, D.S.; Claramunt, R.M.; Elguero, J. Molecular Recognition Studies on Naphthyridine Derivatives. Molecules 2010, 15, 1213-1222.
Iglesias-Sánchez JC, María DS, Claramunt RM, Elguero J. Molecular Recognition Studies on Naphthyridine Derivatives. Molecules. 2010; 15(3):1213-1222.Chicago/Turabian Style
Iglesias-Sánchez, José Carlos; María, Dolores Santa; Claramunt, Rosa M.; Elguero, José. 2010. "Molecular Recognition Studies on Naphthyridine Derivatives." Molecules 15, no. 3: 1213-1222.