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Molecules 2010, 15(3), 1213-1222; doi:10.3390/molecules15031213

Molecular Recognition Studies on Naphthyridine Derivatives

1
Departamento de Química Orgánica y Bio-Orgánica, Facultad de Ciencias, UNED, Senda del Rey 9, E-28040 Madrid, Spain
2
Instituto de Química Médica, CSIC, Juan de la Cierva 3, E-28006, Madrid, Spain
*
Author to whom correspondence should be addressed.
Received: 14 January 2010 / Revised: 8 February 2010 / Accepted: 1 March 2010 / Published: 3 March 2010
(This article belongs to the Special Issue ECSOC-13)
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Abstract

The association constants Kb of three hosts IIII designed to have both enhanced hydrogen bonding donor strength and conformational preorganization with biotin analogues 15 are reported. 1H-NMR titrations under two different concentration conditions have been employed to determine the association constants Kb. A statistical analysis using a presence absence matrix has been applied to calculate the different contributions. Hydrogen bond interactions make naphthyridine derivatives II and III potent binders and effective receptors for (+)-biotin methyl ester (1), due to the complex stabilization by additional hydrogen bonds.
Keywords: host-guest; naphthyridine; biotin; acridine; NMR titrations host-guest; naphthyridine; biotin; acridine; NMR titrations
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MDPI and ACS Style

Iglesias-Sánchez, J.C.; María, D.S.; Claramunt, R.M.; Elguero, J. Molecular Recognition Studies on Naphthyridine Derivatives. Molecules 2010, 15, 1213-1222.

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