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Current Status of Older and New Purine Nucleoside Analogues in the Treatment of Lymphoproliferative Diseases
Department of Hematology, Medical University of Lodz and Copernicus Memorial Hospital, 93-510 Lodz, Ciolkowskiego 2 Str., Poland
* Author to whom correspondence should be addressed.
Received: 6 January 2009; in revised form: 27 February 2009 / Accepted: 10 March 2009 / Published: 23 March 2009
Abstract: For the past few years more and more new cytotoxic agents active in the treatment of hematological malignancies have been synthesized and become available for either in vitro studies or clinical trials. Among them the class of antineoplastic drugs belonging to the purine nucleoside analogues group (PNAs) plays an important role. Three of them: pentostatin (DCF), cladribine (2-CdA) and fludarabine (FA) were approved by Food and Drug Administration (FDA) for the treatment of hematological malignancies. Recently three novel PNAs: clofarabine (CAFdA), nelarabine (ara-G) and forodesine (immucillin H, BCX-1777) have been synthesized and introduced into preclinical studies and clinical trials. These agents seem to be useful mainly for the treatment of human T-cell proliferative disorders and they are currently undergoing clinical trials in lymphoid malignancies. However, there are also several studies suggesting the role of these drugs in B-cell malignancies. This review will summarize current knowledge concerning the mechanism of action, pharmacologic properties, clinical activity and toxicity of PNAs accepted for use in clinical practice, as well as new agents available for clinical trials.
Keywords: Fludarabine; Cladribine; Pentostatin; Clofarabine; Nelarabine; Forodesine; Purine nucleoside analogues; Mechanism of action; Clinical application
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Robak, T.; Korycka, A.; Lech-Maranda, E.; Robak, P. Current Status of Older and New Purine Nucleoside Analogues in the Treatment of Lymphoproliferative Diseases. Molecules 2009, 14, 1183-1226.
Robak T, Korycka A, Lech-Maranda E, Robak P. Current Status of Older and New Purine Nucleoside Analogues in the Treatment of Lymphoproliferative Diseases. Molecules. 2009; 14(3):1183-1226.
Robak, Tadeusz; Korycka, Anna; Lech-Maranda, Ewa; Robak, Pawel. 2009. "Current Status of Older and New Purine Nucleoside Analogues in the Treatment of Lymphoproliferative Diseases." Molecules 14, no. 3: 1183-1226.