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Molecules 2009, 14(3), 1279-1287; doi:10.3390/molecules14031279
Article

Thermus thermophilus Strains Active in Purine Nucleoside Synthesis

1, 2, 1, 3,*  and 2
1 Biotransformations Group. Servicio de Biotransformaciones Industriales. Parque Científico de Madrid. C/ Santiago Grisolia nº 2. 28760 Tres Cantos. Madrid, Spain 2 Centro de Biología Molecular Severo Ochoa, UAM 28049 Cantoblanco. Madrid. Spain 3 Department of Organic & Pharmaceutical Chemistry. Faculty of Pharmacy. Universidad Complutense, 28040 Madrid, Spain
* Author to whom correspondence should be addressed.
Received: 26 December 2008 / Revised: 25 February 2009 / Accepted: 11 March 2009 / Published: 24 March 2009
(This article belongs to the Special Issue Nucleic Acids)
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Abstract

Several strains of Thermus thermophilus were tested in order to detect purine nucleoside synthase activity using pyrimidine nucleosides as the sugar-donor and adenine or hypoxanthine as bases. High productivity values (t =1 hr) were obtained while completely avoiding adenosine-deaminase degradation of the products. N-2-deoxy-ribosyltransferase activity is described for the first time in hyperthermophilic bacteria.
Keywords: Biocatalysis; Nucleoside synthesis; Thermus thermophilus Biocatalysis; Nucleoside synthesis; Thermus thermophilus
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Almendros, M.; Gago, J.-V.; Carlos, J.B. Thermus thermophilus Strains Active in Purine Nucleoside Synthesis. Molecules 2009, 14, 1279-1287.

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