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Molecules 2009, 14(3), 1279-1287; doi:10.3390/molecules14031279

Thermus thermophilus Strains Active in Purine Nucleoside Synthesis

1, 2, 1, 3,*  and 2
1 Biotransformations Group. Servicio de Biotransformaciones Industriales. Parque Científico de Madrid. C/ Santiago Grisolia nº 2. 28760 Tres Cantos. Madrid, Spain 2 Centro de Biología Molecular Severo Ochoa, UAM 28049 Cantoblanco. Madrid. Spain 3 Department of Organic & Pharmaceutical Chemistry. Faculty of Pharmacy. Universidad Complutense, 28040 Madrid, Spain
* Author to whom correspondence should be addressed.
Received: 26 December 2008 / Revised: 25 February 2009 / Accepted: 11 March 2009 / Published: 24 March 2009
(This article belongs to the Special Issue Nucleic Acids)
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Several strains of Thermus thermophilus were tested in order to detect purine nucleoside synthase activity using pyrimidine nucleosides as the sugar-donor and adenine or hypoxanthine as bases. High productivity values (t =1 hr) were obtained while completely avoiding adenosine-deaminase degradation of the products. N-2-deoxy-ribosyltransferase activity is described for the first time in hyperthermophilic bacteria.
Keywords: Biocatalysis; Nucleoside synthesis; Thermus thermophilus Biocatalysis; Nucleoside synthesis; Thermus thermophilus
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Almendros, M.; Gago, J.-V.; Carlos, J.B. Thermus thermophilus Strains Active in Purine Nucleoside Synthesis. Molecules 2009, 14, 1279-1287.

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