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Grandine A, a New Proaporphine Alkaloid from the Bark of Phoebe grandis
Centre for Natural Products and Drug Discovery, Block D, Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia
Institut de Chimie des Substances Naturelles, Centre Nationale de la Recherche Scientifique, UPR2301, 91198, Gif-sur-Yvette, Cedex, France
Department of Chemical Sciences, Faculty of Science and Technology, Universiti Malaysia Terengganu, 21030 Kuala Terengganu, Terengganu, Malaysia
* Author to whom correspondence should be addressed.
Received: 23 December 2008; in revised form: 13 February 2009 / Accepted: 18 February 2009 / Published: 23 March 2009
Abstract: The stem bark of Phoebe grandis afforded one new oxoproaporphine; (–)-grandine A (1), along with six known isoquinoline alkaloids: (–)-8,9-dihydrolinearisine (2), boldine, norboldine, lauformine, scortechiniine A and scortechiniine B. In addition to that of the new compound, complete 1H- and 13C-NMR data of the tetrahydroproaporphine (–)-8,9-dihydrolinearisine (2) is also reported. The alkaloids’ structures were elucidated primarily by means of high field 1D- and 2D-NMR and HRMS spectral data.
Keywords: Oxoproaporphine; NMR; Phoebe grandis; Aporphine; Dihydrolinearisine
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Mukhtar, M.R.; Aziz, A.N.; Thomas, N.F.; Hadi, A.H.A.; Litaudon, M.; Awang, K. Grandine A, a New Proaporphine Alkaloid from the Bark of Phoebe grandis. Molecules 2009, 14, 1227-1233.
Mukhtar MR, Aziz AN, Thomas NF, Hadi AHA, Litaudon M, Awang K. Grandine A, a New Proaporphine Alkaloid from the Bark of Phoebe grandis. Molecules. 2009; 14(3):1227-1233.
Mukhtar, Mat Ropi; Aziz, Ahmad Nazif; Thomas, Noel F.; Hadi, A. Hamid A.; Litaudon, Marc; Awang, Khalijah. 2009. "Grandine A, a New Proaporphine Alkaloid from the Bark of Phoebe grandis." Molecules 14, no. 3: 1227-1233.