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Molecules 2009, 14(3), 1227-1233; doi:10.3390/molecules14031227

Grandine A, a New Proaporphine Alkaloid from the Bark of Phoebe grandis

1 Centre for Natural Products and Drug Discovery, Block D, Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia 2 Institut de Chimie des Substances Naturelles, Centre Nationale de la Recherche Scientifique, UPR2301, 91198, Gif-sur-Yvette, Cedex, France 3 Department of Chemical Sciences, Faculty of Science and Technology, Universiti Malaysia Terengganu, 21030 Kuala Terengganu, Terengganu, Malaysia
* Author to whom correspondence should be addressed.
Received: 23 December 2008 / Revised: 13 February 2009 / Accepted: 18 February 2009 / Published: 23 March 2009
(This article belongs to the Special Issue Aporphines and Oxoaporphines)
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The stem bark of Phoebe grandis afforded one new oxoproaporphine; (–)-grandine A (1), along with six known isoquinoline alkaloids: (–)-8,9-dihydrolinearisine (2), boldine, norboldine, lauformine, scortechiniine A and scortechiniine B. In addition to that of the new compound, complete 1H- and 13C-NMR data of the tetrahydroproaporphine (–)-8,9-dihydrolinearisine (2) is also reported. The alkaloids’ structures were elucidated primarily by means of high field 1D- and 2D-NMR and HRMS spectral data.
Keywords: Oxoproaporphine; NMR; Phoebe grandis; Aporphine; Dihydrolinearisine Oxoproaporphine; NMR; Phoebe grandis; Aporphine; Dihydrolinearisine
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Mukhtar, M.R.; Aziz, A.N.; Thomas, N.F.; Hadi, A.H.A.; Litaudon, M.; Awang, K. Grandine A, a New Proaporphine Alkaloid from the Bark of Phoebe grandis. Molecules 2009, 14, 1227-1233.

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