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MALDI-TOF MS Profiling of Annonaceous Acetogenins in Annona muricata Products for Human Consumption
Laboratoire de Pharmacognosie, CNRS UMR 8076 BioCIS, Faculté de Pharmacie, Université Paris-Sud 11, Rue J. B. Clément, 92296 Châtenay-Malabry, France
Équipe de Spectrométrie de Masse, Institut de Chimie des Substances Naturelles, CNRS UPR2301, 91198 Gif-sur-Yvette, France
* Author to whom correspondence should be addressed.
Received: 20 October 2009; in revised form: 5 December 2009 / Accepted: 10 December 2009 / Published: 15 December 2009
Abstract: Annonaceous acetogenins are proposed as environmental neurotoxicants consumed through medicinal and alimentary habits and responsible for atypical parkinsonian syndromes observed in tropical areas. Potential sources of exposure still have to be determined, as, to date, only a few batches of products for human consumption were searched for these compounds. To assess the presence of acetogenins, we propose a fast, sensitive and accurate method of screening, using MALDI-TOF MS, with minimal sample preparation. Development of the technique is discussed. Its application to leaves of herbal tea, pulp and bottled nectar of Annona muricata is presented.
Keywords: Annona muricata; annonaceae; annonaceous acetogenin; annonacin; guadeloupean parkinsonism; MALDI-TOF MS
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Champy, P.; Guérineau, V.; Laprévote, O. MALDI-TOF MS Profiling of Annonaceous Acetogenins in Annona muricata Products for Human Consumption. Molecules 2009, 14, 5235-5246.
Champy P, Guérineau V, Laprévote O. MALDI-TOF MS Profiling of Annonaceous Acetogenins in Annona muricata Products for Human Consumption. Molecules. 2009; 14(12):5235-5246.
Champy, Pierre; Guérineau, Vincent; Laprévote, Olivier. 2009. "MALDI-TOF MS Profiling of Annonaceous Acetogenins in Annona muricata Products for Human Consumption." Molecules 14, no. 12: 5235-5246.