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Molecules 2009, 14(12), 5235-5246; doi:10.3390/molecules14125235

MALDI-TOF MS Profiling of Annonaceous Acetogenins in Annona muricata Products for Human Consumption

1
Laboratoire de Pharmacognosie, CNRS UMR 8076 BioCIS, Faculté de Pharmacie, Université Paris-Sud 11, Rue J. B. Clément, 92296 Châtenay-Malabry, France
2
Équipe de Spectrométrie de Masse, Institut de Chimie des Substances Naturelles, CNRS UPR2301, 91198 Gif-sur-Yvette, France
*
Author to whom correspondence should be addressed.
Received: 20 October 2009 / Revised: 5 December 2009 / Accepted: 10 December 2009 / Published: 15 December 2009
(This article belongs to the Special Issue Acetogenins: Extraction, Synthesis and Biological Properties)
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Abstract

Annonaceous acetogenins are proposed as environmental neurotoxicants consumed through medicinal and alimentary habits and responsible for atypical parkinsonian syndromes observed in tropical areas. Potential sources of exposure still have to be determined, as, to date, only a few batches of products for human consumption were searched for these compounds. To assess the presence of acetogenins, we propose a fast, sensitive and accurate method of screening, using MALDI-TOF MS, with minimal sample preparation. Development of the technique is discussed. Its application to leaves of herbal tea, pulp and bottled nectar of Annona muricata is presented.
Keywords: Annona muricata; annonaceae; annonaceous acetogenin; annonacin; guadeloupean parkinsonism; MALDI-TOF MS Annona muricata; annonaceae; annonaceous acetogenin; annonacin; guadeloupean parkinsonism; MALDI-TOF MS
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Champy, P.; Guérineau, V.; Laprévote, O. MALDI-TOF MS Profiling of Annonaceous Acetogenins in Annona muricata Products for Human Consumption. Molecules 2009, 14, 5235-5246.

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