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Apolar Annonaceous Acetogenins from the Fruit Pulp of Annona muricata
Molecules 2009, 14(12), 5235-5246; doi:10.3390/molecules14125235
Communication

MALDI-TOF MS Profiling of Annonaceous Acetogenins in Annona muricata Products for Human Consumption

1,* , 2
 and
1
Received: 20 October 2009 / Revised: 5 December 2009 / Accepted: 10 December 2009 / Published: 15 December 2009
(This article belongs to the Special Issue Acetogenins: Extraction, Synthesis and Biological Properties)
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Abstract

Annonaceous acetogenins are proposed as environmental neurotoxicants consumed through medicinal and alimentary habits and responsible for atypical parkinsonian syndromes observed in tropical areas. Potential sources of exposure still have to be determined, as, to date, only a few batches of products for human consumption were searched for these compounds. To assess the presence of acetogenins, we propose a fast, sensitive and accurate method of screening, using MALDI-TOF MS, with minimal sample preparation. Development of the technique is discussed. Its application to leaves of herbal tea, pulp and bottled nectar of Annona muricata is presented.
Keywords: Annona muricata; annonaceae; annonaceous acetogenin; annonacin; guadeloupean parkinsonism; MALDI-TOF MS Annona muricata; annonaceae; annonaceous acetogenin; annonacin; guadeloupean parkinsonism; MALDI-TOF MS
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Champy, P.; Guérineau, V.; Laprévote, O. MALDI-TOF MS Profiling of Annonaceous Acetogenins in Annona muricata Products for Human Consumption. Molecules 2009, 14, 5235-5246.

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