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Molecules 2009, 14(12), 5247-5280; doi:10.3390/molecules14125247
Article

1-Arylsulfonyl-2-(Pyridylmethylsulfinyl) Benzimidazoles as New Proton Pump Inhibitor Prodrugs

1,* , 1,* , 1
 and
2
Received: 9 October 2009 / Revised: 8 December 2009 / Accepted: 14 December 2009 / Published: 15 December 2009
(This article belongs to the collection Prodrugs)
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Abstract

New arylsulfonyl proton pump inhibitor (PPI) prodrug forms were synthesized. These prodrugs provided longer residence time of an effective PPI plasma concentration, resulting in better gastric acid inhibition.
Keywords: proton pump inhibitor; prodrug; gastric acid secretion proton pump inhibitor; prodrug; gastric acid secretion
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Shin, J.M.; Sachs, G.; Cho, Y.-M.; Garst, M. 1-Arylsulfonyl-2-(Pyridylmethylsulfinyl) Benzimidazoles as New Proton Pump Inhibitor Prodrugs. Molecules 2009, 14, 5247-5280.

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