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Molecules 2009, 14(12), 5247-5280; doi:10.3390/molecules14125247

1-Arylsulfonyl-2-(Pyridylmethylsulfinyl) Benzimidazoles as New Proton Pump Inhibitor Prodrugs

1
Department of Physiology, David Geffen School of Medicine, University of California at Los Angeles, and VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
2
Allergan, Inc. Irvine, California 92660, USA
*
Authors to whom correspondence should be addressed.
Received: 9 October 2009 / Revised: 8 December 2009 / Accepted: 14 December 2009 / Published: 15 December 2009
(This article belongs to the Special Issue Prodrugs)
Download PDF [394 KB, uploaded 18 June 2014]

Abstract

New arylsulfonyl proton pump inhibitor (PPI) prodrug forms were synthesized. These prodrugs provided longer residence time of an effective PPI plasma concentration, resulting in better gastric acid inhibition.
Keywords: proton pump inhibitor; prodrug; gastric acid secretion proton pump inhibitor; prodrug; gastric acid secretion
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Shin, J.M.; Sachs, G.; Cho, Y.-M.; Garst, M. 1-Arylsulfonyl-2-(Pyridylmethylsulfinyl) Benzimidazoles as New Proton Pump Inhibitor Prodrugs. Molecules 2009, 14, 5247-5280.

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