Molecules 2009, 14(12), 5247-5280; doi:10.3390/molecules14125247
Article

1-Arylsulfonyl-2-(Pyridylmethylsulfinyl) Benzimidazoles as New Proton Pump Inhibitor Prodrugs

Jai Moo Shin 1,* email, George Sachs 1,* email, Young-moon Cho 1 email and Michael Garst 2 email
1 Department of Physiology, David Geffen School of Medicine, University of California at Los Angeles, and VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA 2 Allergan, Inc. Irvine, California 92660, USA
* Authors to whom correspondence should be addressed.
Received: 9 October 2009; in revised form: 8 December 2009 / Accepted: 14 December 2009 / Published: 15 December 2009
(This article belongs to the Special Issue Prodrugs)
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Abstract: New arylsulfonyl proton pump inhibitor (PPI) prodrug forms were synthesized. These prodrugs provided longer residence time of an effective PPI plasma concentration, resulting in better gastric acid inhibition.
Keywords: proton pump inhibitor; prodrug; gastric acid secretion

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Cite This Article

MDPI and ACS Style

Shin, J.M.; Sachs, G.; Cho, Y.-M.; Garst, M. 1-Arylsulfonyl-2-(Pyridylmethylsulfinyl) Benzimidazoles as New Proton Pump Inhibitor Prodrugs. Molecules 2009, 14, 5247-5280.

AMA Style

Shin JM, Sachs G, Cho Y-M, Garst M. 1-Arylsulfonyl-2-(Pyridylmethylsulfinyl) Benzimidazoles as New Proton Pump Inhibitor Prodrugs. Molecules. 2009; 14(12):5247-5280.

Chicago/Turabian Style

Shin, Jai Moo; Sachs, George; Cho, Young-moon; Garst, Michael. 2009. "1-Arylsulfonyl-2-(Pyridylmethylsulfinyl) Benzimidazoles as New Proton Pump Inhibitor Prodrugs." Molecules 14, no. 12: 5247-5280.

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