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Molecules 2009, 14(12), 5247-5280; doi:10.3390/molecules14125247

1-Arylsulfonyl-2-(Pyridylmethylsulfinyl) Benzimidazoles as New Proton Pump Inhibitor Prodrugs

Department of Physiology, David Geffen School of Medicine, University of California at Los Angeles, and VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
Allergan, Inc. Irvine, California 92660, USA
Authors to whom correspondence should be addressed.
Received: 9 October 2009 / Revised: 8 December 2009 / Accepted: 14 December 2009 / Published: 15 December 2009
(This article belongs to the Special Issue Prodrugs)
Download PDF [394 KB, uploaded 18 June 2014]


New arylsulfonyl proton pump inhibitor (PPI) prodrug forms were synthesized. These prodrugs provided longer residence time of an effective PPI plasma concentration, resulting in better gastric acid inhibition.
Keywords: proton pump inhibitor; prodrug; gastric acid secretion proton pump inhibitor; prodrug; gastric acid secretion
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Shin, J.M.; Sachs, G.; Cho, Y.-M.; Garst, M. 1-Arylsulfonyl-2-(Pyridylmethylsulfinyl) Benzimidazoles as New Proton Pump Inhibitor Prodrugs. Molecules 2009, 14, 5247-5280.

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