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Special Issue "Acetogenins: Extraction, Synthesis and Biological Properties"

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A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products".

Deadline for manuscript submissions: closed (30 June 2009)

Special Issue Editor

Guest Editor
Dr. Bruno Figadere (Website)

Laboratories of Natural Substances Chemistry (Pharmacognosy), UMR 8076-BioCIS, Faculty of Pharmacy, University Paris-Sud, France
Phone: +33 146 83 55 92
Interests: natural substances chemistry; extraction (chromatographies); structural determination (NMR and mass spectrometry); total synthesis (multi-step; methodology in organometallic synthesis and asymmetric synthesis); pharmacomodulation (cytotoxic; antiparasitic; NCS)

Keywords

  • acetogenins
  • extraction and synthesis
  • biological properties studies

Published Papers (4 papers)

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Research

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Open AccessCommunication MALDI-TOF MS Profiling of Annonaceous Acetogenins in Annona muricata Products for Human Consumption
Molecules 2009, 14(12), 5235-5246; doi:10.3390/molecules14125235
Received: 20 October 2009 / Revised: 5 December 2009 / Accepted: 10 December 2009 / Published: 15 December 2009
Cited by 13 | PDF Full-text (331 KB)
Abstract
Annonaceous acetogenins are proposed as environmental neurotoxicants consumed through medicinal and alimentary habits and responsible for atypical parkinsonian syndromes observed in tropical areas. Potential sources of exposure still have to be determined, as, to date, only a few batches of products for [...] Read more.
Annonaceous acetogenins are proposed as environmental neurotoxicants consumed through medicinal and alimentary habits and responsible for atypical parkinsonian syndromes observed in tropical areas. Potential sources of exposure still have to be determined, as, to date, only a few batches of products for human consumption were searched for these compounds. To assess the presence of acetogenins, we propose a fast, sensitive and accurate method of screening, using MALDI-TOF MS, with minimal sample preparation. Development of the technique is discussed. Its application to leaves of herbal tea, pulp and bottled nectar of Annona muricata is presented. Full article
(This article belongs to the Special Issue Acetogenins: Extraction, Synthesis and Biological Properties)
Open AccessCommunication Apolar Annonaceous Acetogenins from the Fruit Pulp of Annona muricata
Molecules 2009, 14(11), 4387-4395; doi:10.3390/molecules14114387
Received: 22 September 2009 / Revised: 19 October 2009 / Accepted: 22 October 2009 / Published: 2 November 2009
Cited by 10 | PDF Full-text (298 KB)
Abstract
A methylene chloride extract of the pulp of Annona muricata L. was fractionated in search for scarcely functionalized Annonaceous acetogenins (type E). Previously known C-35 and C-37 mono-epoxy unsaturated compounds, epomuricenins-A and -B (1+2) and epomusenins-A and -B (3+4), were obtained. Two [...] Read more.
A methylene chloride extract of the pulp of Annona muricata L. was fractionated in search for scarcely functionalized Annonaceous acetogenins (type E). Previously known C-35 and C-37 mono-epoxy unsaturated compounds, epomuricenins-A and -B (1+2) and epomusenins-A and -B (3+4), were obtained. Two new mono-epoxy saturated C-35 representatives, epomurinins-A and -B (5+6) were also isolated. Full article
(This article belongs to the Special Issue Acetogenins: Extraction, Synthesis and Biological Properties)

Review

Jump to: Research

Open AccessReview Total Synthesis of Annonaceous Acetogenins Belonging to the Non-Adjacent Bis-THF and Non-Adjacent THF-THP Sub-Classes
Molecules 2010, 15(1), 460-501; doi:10.3390/molecules15010460
Received: 14 December 2009 / Accepted: 23 December 2009 / Published: 21 January 2010
Cited by 20 | PDF Full-text (2057 KB)
Abstract The synthesis of the subgroups of acetogenins containing non-adjacent bis-THF and non-adjacent THF-THP core units is reviewed. Specifically, total syntheses of gigantecin, 4-deoxygigantecin, cis-sylvaticin, squamostatin-C, squamostatin-D, sylvaticin and mucocin are discussed. Full article
(This article belongs to the Special Issue Acetogenins: Extraction, Synthesis and Biological Properties)
Open AccessReview Medicinal Chemistry of Annonaceous Acetogenins: Design, Synthesis, and Biological Evaluation of Novel Analogues
Molecules 2009, 14(9), 3621-3661; doi:10.3390/molecules14093621
Received: 4 August 2009 / Revised: 31 August 2009 / Accepted: 11 September 2009 / Published: 17 September 2009
Cited by 46 | PDF Full-text (2839 KB)
Abstract
Most Annonaceous acetogenins are characterized by between one and three THF ring(s) with one or two flanking hydroxyl group(s) in the center of a C32/34 fatty acid, and the terminal carboxylic acid is combined with a 2-propanol unit to form an α,β-unsaturated [...] Read more.
Most Annonaceous acetogenins are characterized by between one and three THF ring(s) with one or two flanking hydroxyl group(s) in the center of a C32/34 fatty acid, and the terminal carboxylic acid is combined with a 2-propanol unit to form an α,β-unsaturated γ-lactone. While many studies have addressed the properties and synthesis of natural acetogenins due to their attractive biological activities and unique structural features, a number of analogues have also been described. This review covers the design, synthesis, and biological evaluation of acetogenin analogues. Full article
(This article belongs to the Special Issue Acetogenins: Extraction, Synthesis and Biological Properties)

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