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Medicinal Chemistry of Annonaceous Acetogenins: Design, Synthesis, and Biological Evaluation of Novel Analogues
Molecules 2009, 14(11), 4387-4395; doi:10.3390/molecules14114387

Apolar Annonaceous Acetogenins from the Fruit Pulp of Annona muricata

1, 2
1 and 1,*
1 Laboratoire de Pharmacognosie, CNRS UMR 8076 BioCIS, Faculté de Pharmacie Paris-Sud 11, Rue J. B. Clément, 92296 Châtenay-Malabry, France 2 Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, Université Cheikh Anta Diop, Dakar, Senegal
* Author to whom correspondence should be addressed.
Received: 22 September 2009 / Revised: 19 October 2009 / Accepted: 22 October 2009 / Published: 2 November 2009
(This article belongs to the Special Issue Acetogenins: Extraction, Synthesis and Biological Properties)
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A methylene chloride extract of the pulp of Annona muricata L. was fractionated in search for scarcely functionalized Annonaceous acetogenins (type E). Previously known C-35 and C-37 mono-epoxy unsaturated compounds, epomuricenins-A and -B (1+2) and epomusenins-A and -B (3+4), were obtained. Two new mono-epoxy saturated C-35 representatives, epomurinins-A and -B (5+6) were also isolated.
Keywords: Annona muricata L.; annonaceae; annonaceous acetogenin Annona muricata L.; annonaceae; annonaceous acetogenin
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Melot, A.; Fall, D.; Gleye, C.; Champy, P. Apolar Annonaceous Acetogenins from the Fruit Pulp of Annona muricata. Molecules 2009, 14, 4387-4395.

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