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Medicinal Chemistry of Annonaceous Acetogenins: Design, Synthesis, and Biological Evaluation of Novel Analogues
Molecules 2009, 14(11), 4387-4395; doi:10.3390/molecules14114387

Apolar Annonaceous Acetogenins from the Fruit Pulp of Annona muricata

1, 2
1 and 1,*
1 Laboratoire de Pharmacognosie, CNRS UMR 8076 BioCIS, Faculté de Pharmacie Paris-Sud 11, Rue J. B. Clément, 92296 Châtenay-Malabry, France 2 Laboratoire de Chimie Thérapeutique, Faculté de Pharmacie, Université Cheikh Anta Diop, Dakar, Senegal
* Author to whom correspondence should be addressed.
Received: 22 September 2009 / Revised: 19 October 2009 / Accepted: 22 October 2009 / Published: 2 November 2009
(This article belongs to the Special Issue Acetogenins: Extraction, Synthesis and Biological Properties)
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A methylene chloride extract of the pulp of Annona muricata L. was fractionated in search for scarcely functionalized Annonaceous acetogenins (type E). Previously known C-35 and C-37 mono-epoxy unsaturated compounds, epomuricenins-A and -B (1+2) and epomusenins-A and -B (3+4), were obtained. Two new mono-epoxy saturated C-35 representatives, epomurinins-A and -B (5+6) were also isolated.
Keywords: Annona muricata L.; annonaceae; annonaceous acetogenin Annona muricata L.; annonaceae; annonaceous acetogenin
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Melot, A.; Fall, D.; Gleye, C.; Champy, P. Apolar Annonaceous Acetogenins from the Fruit Pulp of Annona muricata. Molecules 2009, 14, 4387-4395.

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