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Molecules 2009, 14(12), 5223-5234; doi:10.3390/molecules14125223

Generation of 500-Member Library of 10-Alkyl-2-R1,3-R2-4,10-Dihydrobenzo[4,5]imidazo[1,2-α]pyrimidin-4-ones

Department of Chemistry of Heterocyclic Compounds, SSI “Institute for Single Crystals” of National Academy of Sciences of Ukraine, Lenin Ave. 60, Kharkiv 61001, Ukraine
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Received: 4 November 2009 / Revised: 3 December 2009 / Accepted: 14 December 2009 / Published: 15 December 2009
(This article belongs to the Special Issue Molecular Diversity Feature Papers)
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Abstract

Representative benzimidazopyrimidinones were previously reported to be intercalating antitumor agents. In this work, we used 2-substituted 4,10-dihydrobenzo [4,5]imidazo[1,2-α]pyriminin-4-ones for their diversification by regioselective alkylation. Under the conditions established, the alkylation gave 10-alkyl derivatives which permitted the parallel generation of a 500-member library of the title compounds.
Keywords: benzimidazole; dihydrobenzo[4,5]imidazo[1,2-α]pyrimidin-4-one library; regioselective alkylation; anti-cancer agents benzimidazole; dihydrobenzo[4,5]imidazo[1,2-α]pyrimidin-4-one library; regioselective alkylation; anti-cancer agents
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Sirko, S.M.; Gorobets, N.Y.; Musatov, V.I.; Desenko, S.M. Generation of 500-Member Library of 10-Alkyl-2-R1,3-R2-4,10-Dihydrobenzo[4,5]imidazo[1,2-α]pyrimidin-4-ones. Molecules 2009, 14, 5223-5234.

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