Molecules 2009, 14(12), 5223-5234; doi:10.3390/molecules14125223

Generation of 500-Member Library of 10-Alkyl-2-R1,3-R2-4,10-Dihydrobenzo[4,5]imidazo[1,2-α]pyrimidin-4-ones

Department of Chemistry of Heterocyclic Compounds, SSI “Institute for Single Crystals” of National Academy of Sciences of Ukraine, Lenin Ave. 60, Kharkiv 61001, Ukraine
* Author to whom correspondence should be addressed.
Received: 4 November 2009; in revised form: 3 December 2009 / Accepted: 14 December 2009 / Published: 15 December 2009
(This article belongs to the Special Issue Molecular Diversity Feature Papers)
PDF Full-text Download PDF Full-Text [176 KB, uploaded 16 December 2009 09:16 CET]
Abstract: Representative benzimidazopyrimidinones were previously reported to be intercalating antitumor agents. In this work, we used 2-substituted 4,10-dihydrobenzo [4,5]imidazo[1,2-α]pyriminin-4-ones for their diversification by regioselective alkylation. Under the conditions established, the alkylation gave 10-alkyl derivatives which permitted the parallel generation of a 500-member library of the title compounds.
Keywords: benzimidazole; dihydrobenzo[4,5]imidazo[1,2-α]pyrimidin-4-one library; regioselective alkylation; anti-cancer agents

Article Statistics

Load and display the download statistics.

Citations to this Article

Cite This Article

MDPI and ACS Style

Sirko, S.M.; Gorobets, N.Y.; Musatov, V.I.; Desenko, S.M. Generation of 500-Member Library of 10-Alkyl-2-R1,3-R2-4,10-Dihydrobenzo[4,5]imidazo[1,2-α]pyrimidin-4-ones. Molecules 2009, 14, 5223-5234.

AMA Style

Sirko SM, Gorobets NY, Musatov VI, Desenko SM. Generation of 500-Member Library of 10-Alkyl-2-R1,3-R2-4,10-Dihydrobenzo[4,5]imidazo[1,2-α]pyrimidin-4-ones. Molecules. 2009; 14(12):5223-5234.

Chicago/Turabian Style

Sirko, Svetlana M.; Gorobets, Nikolay Yu.; Musatov, Vladimir I.; Desenko, Sergey M. 2009. "Generation of 500-Member Library of 10-Alkyl-2-R1,3-R2-4,10-Dihydrobenzo[4,5]imidazo[1,2-α]pyrimidin-4-ones." Molecules 14, no. 12: 5223-5234.

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert