Molecules 2009, 14(12), 5223-5234; doi:10.3390/molecules14125223
Article

Generation of 500-Member Library of 10-Alkyl-2-R1,3-R2-4,10-Dihydrobenzo[4,5]imidazo[1,2-α]pyrimidin-4-ones

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Received: 4 November 2009; in revised form: 3 December 2009 / Accepted: 14 December 2009 / Published: 15 December 2009
(This article belongs to the Special Issue Molecular Diversity Feature Papers)
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract: Representative benzimidazopyrimidinones were previously reported to be intercalating antitumor agents. In this work, we used 2-substituted 4,10-dihydrobenzo [4,5]imidazo[1,2-α]pyriminin-4-ones for their diversification by regioselective alkylation. Under the conditions established, the alkylation gave 10-alkyl derivatives which permitted the parallel generation of a 500-member library of the title compounds.
Keywords: benzimidazole; dihydrobenzo[4,5]imidazo[1,2-α]pyrimidin-4-one library; regioselective alkylation; anti-cancer agents
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MDPI and ACS Style

Sirko, S.M.; Gorobets, N.Y.; Musatov, V.I.; Desenko, S.M. Generation of 500-Member Library of 10-Alkyl-2-R1,3-R2-4,10-Dihydrobenzo[4,5]imidazo[1,2-α]pyrimidin-4-ones. Molecules 2009, 14, 5223-5234.

AMA Style

Sirko SM, Gorobets NY, Musatov VI, Desenko SM. Generation of 500-Member Library of 10-Alkyl-2-R1,3-R2-4,10-Dihydrobenzo[4,5]imidazo[1,2-α]pyrimidin-4-ones. Molecules. 2009; 14(12):5223-5234.

Chicago/Turabian Style

Sirko, Svetlana M.; Gorobets, Nikolay Yu.; Musatov, Vladimir I.; Desenko, Sergey M. 2009. "Generation of 500-Member Library of 10-Alkyl-2-R1,3-R2-4,10-Dihydrobenzo[4,5]imidazo[1,2-α]pyrimidin-4-ones." Molecules 14, no. 12: 5223-5234.

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