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Molecules 2009, 14(12), 5223-5234; doi:10.3390/molecules14125223

Generation of 500-Member Library of 10-Alkyl-2-R1,3-R2-4,10-Dihydrobenzo[4,5]imidazo[1,2-α]pyrimidin-4-ones

, * ,  and
Department of Chemistry of Heterocyclic Compounds, SSI “Institute for Single Crystals” of National Academy of Sciences of Ukraine, Lenin Ave. 60, Kharkiv 61001, Ukraine
* Author to whom correspondence should be addressed.
Received: 4 November 2009 / Revised: 3 December 2009 / Accepted: 14 December 2009 / Published: 15 December 2009
(This article belongs to the Special Issue Molecular Diversity Feature Papers)
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Representative benzimidazopyrimidinones were previously reported to be intercalating antitumor agents. In this work, we used 2-substituted 4,10-dihydrobenzo [4,5]imidazo[1,2-α]pyriminin-4-ones for their diversification by regioselective alkylation. Under the conditions established, the alkylation gave 10-alkyl derivatives which permitted the parallel generation of a 500-member library of the title compounds.
Keywords: benzimidazole; dihydrobenzo[4,5]imidazo[1,2-α]pyrimidin-4-one library; regioselective alkylation; anti-cancer agents benzimidazole; dihydrobenzo[4,5]imidazo[1,2-α]pyrimidin-4-one library; regioselective alkylation; anti-cancer agents
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Sirko, S.M.; Gorobets, N.Y.; Musatov, V.I.; Desenko, S.M. Generation of 500-Member Library of 10-Alkyl-2-R1,3-R2-4,10-Dihydrobenzo[4,5]imidazo[1,2-α]pyrimidin-4-ones. Molecules 2009, 14, 5223-5234.

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