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Molecules 2010, 15(1), 460-501; doi:10.3390/molecules15010460
Review

Total Synthesis of Annonaceous Acetogenins Belonging to the Non-Adjacent Bis-THF and Non-Adjacent THF-THP Sub-Classes

 and *
Received: 14 December 2009; Accepted: 23 December 2009 / Published: 21 January 2010
(This article belongs to the Special Issue Acetogenins: Extraction, Synthesis and Biological Properties)
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Abstract: The synthesis of the subgroups of acetogenins containing non-adjacent bis-THF and non-adjacent THF-THP core units is reviewed. Specifically, total syntheses of gigantecin, 4-deoxygigantecin, cis-sylvaticin, squamostatin-C, squamostatin-D, sylvaticin and mucocin are discussed.
Keywords: annonaceous acetogenins; non-adjacent bis-THF; tetrahydrofuran; tetrahydropyran; asymmetric synthesis; 1,2-diols; epoxides; cytotoxic natural products; anti-tumour annonaceous acetogenins; non-adjacent bis-THF; tetrahydrofuran; tetrahydropyran; asymmetric synthesis; 1,2-diols; epoxides; cytotoxic natural products; anti-tumour
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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MDPI and ACS Style

Spurr, I.B.; Brown, R.C.D. Total Synthesis of Annonaceous Acetogenins Belonging to the Non-Adjacent Bis-THF and Non-Adjacent THF-THP Sub-Classes. Molecules 2010, 15, 460-501.

AMA Style

Spurr IB, Brown RCD. Total Synthesis of Annonaceous Acetogenins Belonging to the Non-Adjacent Bis-THF and Non-Adjacent THF-THP Sub-Classes. Molecules. 2010; 15(1):460-501.

Chicago/Turabian Style

Spurr, Ian B.; Brown, Richard C. D. 2010. "Total Synthesis of Annonaceous Acetogenins Belonging to the Non-Adjacent Bis-THF and Non-Adjacent THF-THP Sub-Classes." Molecules 15, no. 1: 460-501.



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