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MALDI-TOF MS Profiling of Annonaceous Acetogenins in Annona muricata Products for Human Consumption
Molecules 2010, 15(1), 460-501; doi:10.3390/molecules15010460
Review

Total Synthesis of Annonaceous Acetogenins Belonging to the Non-Adjacent Bis-THF and Non-Adjacent THF-THP Sub-Classes

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Received: 14 December 2009 / Accepted: 23 December 2009 / Published: 21 January 2010
(This article belongs to the Special Issue Acetogenins: Extraction, Synthesis and Biological Properties)
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Abstract

The synthesis of the subgroups of acetogenins containing non-adjacent bis-THF and non-adjacent THF-THP core units is reviewed. Specifically, total syntheses of gigantecin, 4-deoxygigantecin, cis-sylvaticin, squamostatin-C, squamostatin-D, sylvaticin and mucocin are discussed.
Keywords: annonaceous acetogenins; non-adjacent bis-THF; tetrahydrofuran; tetrahydropyran; asymmetric synthesis; 1,2-diols; epoxides; cytotoxic natural products; anti-tumour annonaceous acetogenins; non-adjacent bis-THF; tetrahydrofuran; tetrahydropyran; asymmetric synthesis; 1,2-diols; epoxides; cytotoxic natural products; anti-tumour
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Spurr, I.B.; Brown, R.C.D. Total Synthesis of Annonaceous Acetogenins Belonging to the Non-Adjacent Bis-THF and Non-Adjacent THF-THP Sub-Classes. Molecules 2010, 15, 460-501.

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