Molecules 2010, 15(1), 460-501; doi:10.3390/molecules15010460
Review

Total Synthesis of Annonaceous Acetogenins Belonging to the Non-Adjacent Bis-THF and Non-Adjacent THF-THP Sub-Classes

The School of Chemistry, The University of Southampton, Highfield, Southampton SO17 1BJ, UK
* Author to whom correspondence should be addressed.
Received: 14 December 2009; Accepted: 23 December 2009 / Published: 21 January 2010
(This article belongs to the Special Issue Acetogenins: Extraction, Synthesis and Biological Properties)
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Abstract: The synthesis of the subgroups of acetogenins containing non-adjacent bis-THF and non-adjacent THF-THP core units is reviewed. Specifically, total syntheses of gigantecin, 4-deoxygigantecin, cis-sylvaticin, squamostatin-C, squamostatin-D, sylvaticin and mucocin are discussed.
Keywords: annonaceous acetogenins; non-adjacent bis-THF; tetrahydrofuran; tetrahydropyran; asymmetric synthesis; 1,2-diols; epoxides; cytotoxic natural products; anti-tumour

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MDPI and ACS Style

Spurr, I.B.; Brown, R.C.D. Total Synthesis of Annonaceous Acetogenins Belonging to the Non-Adjacent Bis-THF and Non-Adjacent THF-THP Sub-Classes. Molecules 2010, 15, 460-501.

AMA Style

Spurr IB, Brown RCD. Total Synthesis of Annonaceous Acetogenins Belonging to the Non-Adjacent Bis-THF and Non-Adjacent THF-THP Sub-Classes. Molecules. 2010; 15(1):460-501.

Chicago/Turabian Style

Spurr, Ian B.; Brown, Richard C. D. 2010. "Total Synthesis of Annonaceous Acetogenins Belonging to the Non-Adjacent Bis-THF and Non-Adjacent THF-THP Sub-Classes." Molecules 15, no. 1: 460-501.

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