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Molecules 2010, 15(1), 460-501; https://doi.org/10.3390/molecules15010460

Total Synthesis of Annonaceous Acetogenins Belonging to the Non-Adjacent Bis-THF and Non-Adjacent THF-THP Sub-Classes

The School of Chemistry, The University of Southampton, Highfield, Southampton SO17 1BJ, UK
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Received: 14 December 2009 / Accepted: 23 December 2009 / Published: 21 January 2010
(This article belongs to the Special Issue Acetogenins: Extraction, Synthesis and Biological Properties)
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Abstract

The synthesis of the subgroups of acetogenins containing non-adjacent bis-THF and non-adjacent THF-THP core units is reviewed. Specifically, total syntheses of gigantecin, 4-deoxygigantecin, cis-sylvaticin, squamostatin-C, squamostatin-D, sylvaticin and mucocin are discussed.
Keywords: annonaceous acetogenins; non-adjacent bis-THF; tetrahydrofuran; tetrahydropyran; asymmetric synthesis; 1,2-diols; epoxides; cytotoxic natural products; anti-tumour annonaceous acetogenins; non-adjacent bis-THF; tetrahydrofuran; tetrahydropyran; asymmetric synthesis; 1,2-diols; epoxides; cytotoxic natural products; anti-tumour
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
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Spurr, I.B.; Brown, R.C.D. Total Synthesis of Annonaceous Acetogenins Belonging to the Non-Adjacent Bis-THF and Non-Adjacent THF-THP Sub-Classes. Molecules 2010, 15, 460-501.

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