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Molecules 2010, 15(1), 460-501; doi:10.3390/molecules15010460
Review
Total Synthesis of Annonaceous Acetogenins Belonging to the Non-Adjacent Bis-THF and Non-Adjacent THF-THP Sub-Classes
Ian B. Spurr 
and Richard C. D. Brown *
and Richard C. D. Brown *
The School of Chemistry, The University of Southampton, Highfield, Southampton SO17 1BJ, UK
* Author to whom correspondence should be addressed.
Received: 14 December 2009 / Accepted: 23 December 2009 / Published: 21 January 2010
(This article belongs to the Special Issue Acetogenins: Extraction, Synthesis and Biological Properties)
Download PDF Full-Text [2057 KB, Version of Record, uploaded 21 January 2010 10:21 CET]
Abstract: The synthesis of the subgroups of acetogenins containing non-adjacent bis-THF and non-adjacent THF-THP core units is reviewed. Specifically, total syntheses of gigantecin, 4-deoxygigantecin, cis-sylvaticin, squamostatin-C, squamostatin-D, sylvaticin and mucocin are discussed.
Keywords: annonaceous acetogenins; non-adjacent bis-THF; tetrahydrofuran; tetrahydropyran; asymmetric synthesis; 1,2-diols; epoxides; cytotoxic natural products; anti-tumour
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MDPI and ACS Style
Spurr, I.B.; Brown, R.C.D. Total Synthesis of Annonaceous Acetogenins Belonging to the Non-Adjacent Bis-THF and Non-Adjacent THF-THP Sub-Classes. Molecules 2010, 15, 460-501.
AMA StyleSpurr I.B., Brown R.C.D. Total Synthesis of Annonaceous Acetogenins Belonging to the Non-Adjacent Bis-THF and Non-Adjacent THF-THP Sub-Classes. Molecules. 2010; 15(1):460-501.
Chicago/Turabian StyleSpurr, Ian B.; Brown, Richard C. D. 2010. "Total Synthesis of Annonaceous Acetogenins Belonging to the Non-Adjacent Bis-THF and Non-Adjacent THF-THP Sub-Classes." Molecules 15, no. 1: 460-501.
Molecules
EISSN 1420-3049
Published by MDPI Publishing, Basel, Switzerland
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