Special Issue "Humoral Responses Against HCV"

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A special issue of Viruses (ISSN 1999-4915).

Deadline for manuscript submissions: 30 April 2014

Special Issue Editor

Guest Editor
Dr. François-Loïc Cosset
Human Virology Department, Inserm U758 - Ecole Normale Supérieure de Lyon, 46 allée d'Italie, 69364 Lyon, Cedex 07, France
Website: http://cvscience.aviesan.fr/cv/883/francois-loic-cosset
E-Mail: flclosset@ens-lyon.fr
Phone: +33 472 72 87 32
Fax: +33 472 72 81 37
Interests: properties of the viral surface glycoproteins derived from retroviruses; flaviviruses; hepaciviruses and influenza viruses; development of novel gene transfer vectors and viral engineering techniques

Special Issue Information

Dear Colleagues,

Hepatitis C virus (HCV) infection is a major cause of chronic liver disease world-wide. With 180 million persistently infected people chronic hepatitis C infection represents a major public health problem of high socio-economic impact. Treatment options for chronic hepatitis C are limited and a vaccine for prevention against HCV infection is not available. The investigation of the humoral response against HCV and therefore the development of potent B cell immunogens, that have greatly suffered from the paucity of HCV in vitro infection assays, is essential. Owing to recent essential progresses in the field,  the current limitations in vaccine development should be overcome by addressing the improvement of B cell responses. This should be achieved by a thorough investigation: i) of mechanisms of neutralization or escape from neutralizing antibodies, ii) of influence of serum factors - e.g., lipoproteins - that can modulate and/or counteract both cell entry and neutralization and iii) of cell entry steps that can potentially be targeted by antibodies, including those that are not raised naturally. Identifying successful immune responses against HCV and those naturally occurring in individuals spontaneously clearing infection might guide efforts to elicit such immune responses by appropriate vaccination and to produce effective neutralizing antibodies for passive immunization.

Dr. François-Loïc Cosset
Guest Editor

Submission

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed Open Access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs).

Keywords

  • hepatitis C virus
  • neutralizing antibody
  • immune correlates
  • therapy
  • monoclonals
  • viral cell entry
  • antivirals and viral escape
  • vaccines

Published Papers (3 papers)

Viruses 2011, 3(11), 2280-2300; doi:10.3390/v3112280
Received: 8 September 2011; in revised form: 28 October 2011 / Accepted: 7 November 2011 / Published: 15 November 2011
Show/Hide Abstract | Download PDF Full-text (274 KB)

Viruses 2011, 3(11), 2127-2145; doi:10.3390/v3112127
Received: 14 September 2011; in revised form: 18 October 2011 / Accepted: 22 October 2011 / Published: 2 November 2011
Show/Hide Abstract | Download PDF Full-text (1823 KB)

Viruses 2011, 3(10), 1909-1932; doi:10.3390/v3101909
Received: 27 July 2011; in revised form: 28 September 2011 / Accepted: 1 October 2011 / Published: 14 October 2011
Show/Hide Abstract | Download PDF Full-text (425 KB)

Last update: 23 October 2013

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