Special Issue "Ion Channel Neurotoxins"
A special issue of Toxins (ISSN 2072-6651).
Deadline for manuscript submissions: closed (31 August 2014)
Dr. Jean-Marc Sabatier
Laboratory INSERM UMR 1097, Aix-Marseille University, 163, Parc Scientifique et Technologique de Luminy, Avenue de Luminy, Bâtiment TPR2, Case 939, Marseille 13288, France
Phone: +33 491 82 87 50
Fax: +33 491 83 09 26
Interests: chemical synthesis; peptide synthesis; structure-activity relationships; medicinal chemistry; candidate drugs; antivirals, antibacterials; antioxidants; toxins
Animal venoms (scorpions, snakes, cone snails, worms, sea anemones, frogs, wasps, etc.) are invaluable sources of pharmacologically-active compounds with various molecular targets. Among venom compounds, peptide toxins target the diverse ion channels (potassium, calcium, sodium and chloride channels). These molecules are often highly potent, more or less selective and, sometimes, have a potential therapeutic value depending on their cellular targets. Some peptide toxins are structurally optimized to be developed as candidate drugs to treat pain and specific human pathologies, such as autoimmune and neurological disorders. This special issue of ‘Toxins’ deals with all aspects of the venomous molecules, including structural properties, pharmacology, structure-activity relationships, toxin-based drug design, toxin engineering and development as chemotherapeutic drugs.
Dr. Jean-Marc Sabatier
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed Open Access monthly journal published by MDPI.
- animal toxin
- venomous animal
- ion channel
- ion channel modulator
- drug design
- toxin engineering
- chemotherapeutic drug