Special Issue "Ion Channel Neurotoxins"
A special issue of Toxins (ISSN 2072-6651).
Deadline for manuscript submissions: closed (31 August 2014)
Dr. Jean-Marc Sabatier
Laboratory INSERM U1097-ERT 62 'Ingenierie des Peptides a Visee Therapeutique', Universite de la Mediterranee, Faculte de Medecine Nord, Boulevard Pierre Dramard, 13916 Marseille, Cedex 20, France
Fax: +33 442 29 16 12
Interests: toxinology; animal toxins; ion channel blockers; toxin-derived drug; drug design; peptide and protein engineering; therapy
Animal venoms (scorpions, snakes, cone snails, worms, sea anemones, frogs, wasps, etc.) are invaluable sources of pharmacologically-active compounds with various molecular targets. Among venom compounds, peptide toxins target the diverse ion channels (potassium, calcium, sodium and chloride channels). These molecules are often highly potent, more or less selective and, sometimes, have a potential therapeutic value depending on their cellular targets. Some peptide toxins are structurally optimized to be developed as candidate drugs to treat pain and specific human pathologies, such as autoimmune and neurological disorders. This special issue of ‘Toxins’ deals with all aspects of the venomous molecules, including structural properties, pharmacology, structure-activity relationships, toxin-based drug design, toxin engineering and development as chemotherapeutic drugs.
Dr. Jean-Marc Sabatier
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed Open Access monthly journal published by MDPI.
- animal toxin
- venomous animal
- ion channel
- ion channel modulator
- drug design
- toxin engineering
- chemotherapeutic drug