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Special Issue "Foodborne Toxins: Pathogenesis and Novel Control Measures"

A special issue of Toxins (ISSN 2072-6651).

Deadline for manuscript submissions: 31 July 2018

Special Issue Editor

Guest Editor
Dr. Luisa W. Cheng

Western Regional Research Center, Foodborne Toxin Detection and Prevention Research Unit, USDA-ARS, Albany, CA, 94710, USA
Interests: botulinum neurotoxins; shiga toxins; mycotoxins; abrin and ricin toxins

Special Issue Information

Dear Colleagues,

The causative agents of foodborne diseases vary greatly, ranging from bacteria, fungi, viruses, parasites, plants, to chemicals. In many cases, the production of toxins and subsequent intoxication of the host after oral ingestion of contaminated foods leads to the development of disease. However, the pathogenesis of toxins produced by microbes, plants or fungi are not well understood and methods for toxin control and prevention are lacking. Recently, investigations of foodborne outbreaks also provided new insights about those newly described bacterial toxins, which are not typically regarded as foodborne pathogens. Therefore, to ensure a safe food supply, increased understanding of how foodborne toxins cause diseases is a must. New methods to control production, and inactivate foodborne toxins from known and unknown pathogens in a variety of complex matrices must be developed to aid food processors and regulatory agencies to adqueately monitor the safety of our food. In addition, development of new countermeasures, such as drugs or vaccines against such toxins would help combat foodborne intoxications.

This Special Issue will focus on the pathogenesis of foodborne toxins, new methods of toxin control or therapeutic interventions and new vaccines or countermeasures against of the foodborne toxins.

Dr. Luisa W. Cheng
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • foodborne toxins
  • pathogenesis
  • toxin inactivation
  • bioavailability
  • vaccines
  • food safety
  • biocontrol

Published Papers (1 paper)

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Open AccessArticle Changes in Phenylpropanoid and Trichothecene Production by Fusarium culmorum and F. graminearum Sensu Stricto via Exposure to Flavonoids
Received: 13 February 2018 / Revised: 2 March 2018 / Accepted: 3 March 2018 / Published: 5 March 2018
PDF Full-text (485 KB) | HTML Full-text | XML Full-text | Supplementary Files
Flavonoids are a group of hydroxylated polyphenolic compounds widely distributed in the plant kingdom. Biosynthesis of these compounds involves type III PKSs, whose presence has been recently predicted in some fungal species through genome sequencing efforts. In this study, for the first time
[...] Read more.
Flavonoids are a group of hydroxylated polyphenolic compounds widely distributed in the plant kingdom. Biosynthesis of these compounds involves type III PKSs, whose presence has been recently predicted in some fungal species through genome sequencing efforts. In this study, for the first time it was found that Fusaria produce flavonoids on solid YES medium. Naringenin, as the central precursor of all flavonoids, was produced at highest quantities, followed by quercetin, kaempferol, apigenin and luteolin. In plants, flavonoids are involved in the protection of cereals to a wide range of stresses, including host defense against Fusaria. Under in vitro conditions, strains of Fusarium culmorum and F. graminearum sensu stricto were incubated at levels of flavonoids close to amounts produced by cereals in response to fungal infection. The amounts of exogenous naringenin, apigenin, luteolin, kaempferol and quercetin were reduced and converted by fungi to the other flavonoid derivatives. Treatment of fungi with naringenin derivatives led to the inhibition of naringenin production. Correspondingly, the production of fungal-derived phenolic acids decreased in flavonoid treated samples, although this effect appeared to be dependent on the strain, flavonoid molecule and its concentration. Fusaria showed high variability in trichothecene production in response to flavonoids. With emphasis on quercetin, mycotoxin accumulation in the media was significantly decreased by luteolin, kaempferol, naringenin and apigenin. However, in some cases, apigenin led to the increase of mycotoxin content in the media. Gene expression experiments of Tri genes responsible for trichothecene biosynthesis (Tri4, Tri5 and Tri10) proved that the inhibition of mycotoxin production by flavonoids occurred at the transcriptional level. However, the changes in Tri transcript levels were not significant in most apigenin and all kaempferol-treated cultures. In this study, a link was established between antioxidant and antiradical properties of flavonoids and their effects on fungi. Full article
(This article belongs to the Special Issue Foodborne Toxins: Pathogenesis and Novel Control Measures)

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