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Special Issue "Leukotoxins"

A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Bacterial Toxins".

Deadline for manuscript submissions: 30 June 2018

Special Issue Editor

Guest Editor
Prof. Subramaniam Srikumaran

Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164-7040, USA
Phone: 509-432-5620
Fax: 509-335-8529
Interests: Mannheimia haemolytica; Leukotoxins; Host-Pathogen interactions; Strategies for development of disease-resistant animals; Vaccines

Special Issue Information

Dear Colleagues,

Leukotoxins are the critical virulence factors of several Gram-positive and Gram-negative bacteria. Leukotoxin-deletion mutants exhibit drastically reduced virulence, emphasizing the importance of these toxins as virulence factors in the pathogenesis of these bacteria. By targeting all the subsets of leukocytes, they impair the ability of the hosts to mount an effective immune response.  Some of them have haemolytic activity as well.  In some cases, the effects on the target cells are multiple, depending on the concentration. At high concentrations, they cause target cell lysis while at low concentrations they induce the production of immuno-modulatory molecules. The lytic mechanisms include apoptosis and necrosis. Intriguingly, some leukotoxins use the host cell molecules involved in the orchestration of the immune response, as their receptors.  This special issue will focus on recent advances in areas of research, including but not limited to: (i) molecular evolutionary perspectives on leukotoxins; (ii) structure-function relationships; (iii) pathogenetic mechanisms; (iv) leukotoxin-receptor interactions; (v) strategies to prevent binding of leukotoxin to target cells; (vi) immune response to leukotoxins; (vii) vaccines that induce anti-leukotoxin immunity.  We encourage submission of original research articles, perspectives, and review articles.

Prof. Subramaniam Srikumaran
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxins is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Leukotoxin
  • Gram-positive
  • Gram-negative
  • host-pathogen interaction
  • pathogenetic mechanisms
  • anti-leukotoxin immunity
  • vaccine

Published Papers

This special issue is now open for submission.
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