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Special Issue "Microcantilever Sensors"

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A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biosensors".

Deadline for manuscript submissions: closed (31 March 2011)

Special Issue Editor

Guest Editor
Prof. Dr. Stephen Elliott

Chemical Physics Group, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK
Website | E-Mail
Interests: (Bio)chemical sensing; microcantilever-array sensors; optical-interferometric cantilever readout; optical-waveguide sensors; surface-enhanced Raman scattering; chalcogenide glasses; phase-change memory materials; ab initio molecular-dynamics simulations of glasses

Special Issue Information

Dear Colleagues,

There is an ever-increasing need for (bio)chemical sensors for a wide variety of applications in the fields of medical diagnostics, wellness and healthcare, proteomics, pharmaceutics, environmental monitoring, homeland security, process control etc. Ideally, sensor devices are required for such applications which are sensitive, selective to a variety of analytes and can give a multiplexed response; for consumer applications, devices must additionally be cheap, robust and compact – ideally hand-held. One very promising sensing technology that can address such application needs involves the use of MEMS structures such as micro/nano-cantilevers, coated with appropriate receptor layers. The use of cantilever-array sensors, in particular, offers the prospect of multiplexed readout. Thus, they have the potential to be used as ‘electronic noses or tongues’. The aim of this Special Issue is to bring together a number of papers on the topic of cantilever sensing which address developments in the sensing technology, as well as in its application.

Prof. Dr. Stephen Elliott
Guest Editor

Keywords

  • cantilever sensors
  • microcantilever
  • nanocantilever
  • MEMS sensors
  • NEMS sensors
  • cantilever arrays
  • multiplexed sensing
  • cantilever readout
  • cantilever-sensor receptor layers
  • chemical sensors
  • biosensors
  • electronic nose
  • electronic tongue

Published Papers (1 paper)

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Research

Open AccessArticle A Rapid Method to Regenerate Piezoelectric Microcantilever Sensors (PEMS)
Sensors 2011, 11(5), 5520-5528; doi:10.3390/s110505520
Received: 15 March 2011 / Revised: 10 May 2011 / Accepted: 17 May 2011 / Published: 20 May 2011
Cited by 4 | PDF Full-text (232 KB) | HTML Full-text | XML Full-text
Abstract
Piezoelectric microcantilever sensors (PEMS) can be sensitive tools for the detection of proteins and cells in biological fluids. However, currently available PEMS can only be used a single time or must be completely stripped and refunctionalized prior to subsequent uses. Here we report
[...] Read more.
Piezoelectric microcantilever sensors (PEMS) can be sensitive tools for the detection of proteins and cells in biological fluids. However, currently available PEMS can only be used a single time or must be completely stripped and refunctionalized prior to subsequent uses. Here we report the successful use of an alternative regeneration protocol employing high salt concentrations to remove the target, leaving the functional probe immobilized on the microcantilever surface. Our model system employed the extracellular domain (ECD) of recombinant human Epidermal Growth Factor Receptor (EGFR) as the probe and anti-human EGFR polyclonal antibodies as the target. We report that high concentrations of MgCl2 dissociated polyclonal antibodies specifically bound to EGFR ECD immobilized on the sensor surface without affecting its bioactivity. This simple regeneration protocol both minimized the time required to re-conjugate the probe and preserved the density of probe immobilized on PEMS surface, yielding identical biosensor sensitivity over a series of assays. Full article
(This article belongs to the Special Issue Microcantilever Sensors)

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