Special Issue "Natural Polymers 2014"
A special issue of Polymers (ISSN 2073-4360).
Deadline for manuscript submissions: closed (31 January 2014)
Prof. Dr. Christine E. Schmidt
Department of Biomedical Engineering, University of Florida, BMSB JG-42, P.O. Box 116131, Gainesville, FL 32611, USA
Phone: +1 352-273-9222
Fax: +1 352-273-9221
Interests: biomaterials; scaffolds; natural polymers; electrically conducting polymers
This Special Issue came as the natural consequence of the great success of the previous one “Natural Polymers”.
Contributions are invited that specifically involve polymers of a natural or biological origin, namely proteins, nucleic acids, and polysaccharides. Of particular interest are research studies or review articles related to the following areas: (1) connections between polymer science fundamentals with the understanding and applications of natural polymers, including the structure, behavior and uses of natural polymers in solutions, complexes and at interfaces with other materials; (2) bioengineering applications of natural polymers, including tissue engineering, clinical medicine, as well as pharmaceutical and food technologies; and we particularly encourage; (3) novel applications of natural polymers, including their use in bioMEMs devices and nanotechnology as well as novel modifications of natural polymers to enhance their properties by functionalization, cross-linking, or forming composite or co-polymer structures with other materials.
Prof. Dr. Christine E. Schmidt
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed Open Access monthly journal published by MDPI.
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Type of Paper: Review
Title: Ultrapure Low Molecular Weight Chitosan (ULMWC)-based Polyplexes for Delivery of pDNA: From the Row Matter to the Clinic
Author: Jon Zarate Sesma
Affiliation: Department of Physiology, Faculty of Pharmacy, University of the Basque Country, Paseo de la Universidad 7, 01006 Vitoria-Gasteiz, Spain; E-Mail: email@example.com
Abstract: The interest of chitosan for pDNA delivery applications lies with the ability to form positively charged nano-sized complexes (polyplexes) when positively charged amine groups bind with negatively charged pDNA. Although commercially available bulk chitosans were typically high molecular weight (Mn) and witha low degree ofdeacetylation(DDA), latter studies suggest low Mn (<150 kDa) and high DDA (>80%) chitosans (ULMWC) to increase transfection efficiency. The purpose of this review is to display an integrated review of all major areas of ultrapure low molecular weight chitosan (ULMWC)-based transfection, including production, ULMWC and polyplexes physicochemical characterisation, in vitro and in vivo assessment. In each, we present the impediments to efficient transfection and the strategies adopted over time to overcome these obstacules.