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Naturapolyceutics: The Science of Utilizing Natural Polymers for Drug Delivery
Polymers 2014, 6(5), 1350-1365; doi:10.3390/polym6051350
Article

Optimization of Biopolymer Based Transdermal Films of Metoclopramide as an Alternative Delivery Approach

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Received: 27 January 2014 / Revised: 29 April 2014 / Accepted: 30 April 2014 / Published: 9 May 2014
(This article belongs to the Special Issue Natural Polymers 2014)
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Abstract

The objectives of this study were to develop and to characterize sodium alginate based matrix-type transdermal films of metoclopramide hydrochloride (MTC) in order to improve patient compliance to treatment. The suitability of sodium alginate was shown to be a natural film former in terms of the physicochemical, mechanical, and bioadhesive features of the MTC loaded transdermal films. Terpinolene provided the highest drug release among the different terpenes (nerolidol, eucalyptol, dl-limonene, or terpinolene) assessed as enhancer. Attenuated Total Reflectance Infrared (ATR-FTIR) spectroscopy analysis performed to evaluate the effect of the transdermal films on skin barrier confirmed enhancer induced lipid bilayer disruption in stratum corneum, indicating its permeation enhancement effect.
Keywords: sodium alginate; natural polymers; metoclopramide; transdermal film; antiemetic drug; terpenes sodium alginate; natural polymers; metoclopramide; transdermal film; antiemetic drug; terpenes
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Aktar, B.; Erdal, M.S.; Sagirli, O.; Güngör, S.; Özsoy, Y. Optimization of Biopolymer Based Transdermal Films of Metoclopramide as an Alternative Delivery Approach. Polymers 2014, 6, 1350-1365.

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