Special Issue "Pharmacokinetics and Pharmacodynamics in Children: Establishing Differences from Adults"
A special issue of Pharmaceutics (ISSN 1999-4923).
Deadline for manuscript submissions: closed (30 November 2010)
Prof. Dr. John F. Marriott
Aston Pharmacy School, Aston University, Aston Triangle, Birmingham B4 7ET, UK
Phone: +44 (0)121 204 3985
Interests: the formulation of drugs for use by children; PK/PD issues in paediatrics; managing medicines in both adult and paediatric contexts; ethics of trial design in paediatrics
From a medical perspective, it is encouraging that children are now generally regarded to be different from adults in terms of therapeutics. These differences are apparent in the areas of drug dynamics and kinetics. However, there is still a paucity of robust data in children informing us of the differences in both pharmacodynamic and pharmacokinetic effects associated with many drugs when compared to adults. In addition, new techniques for the analysis of drug blood levels are required in children. This is of particular relevance in the very young, where only small sample volumes are available and in terms of minimising invasive procedures likely to disturb paediatric study participants.
This special issue will cover evidence of pharmcodynamic and pharmacokinetic effects in children from all age bands, highlighting how these parameters compare to data obtained in the adult population. In addition, material highlighting child friendly approaches to pharmacodynamic and pharmacokinetic studies will be addressed.
Prof. Dr. John F. Marriott
- drug analysis
- drug concentrations
- drug effects/actions
Review: Factors and Mechanisms for Pharmacokinetic Differences between Pediatric Population and Adults
Pharmaceutics 2011, 3(1), 53-72; doi:10.3390/pharmaceutics3010053
Received: 16 December 2010; Accepted: 28 January 2011 / Published: 7 February 2011| Download PDF Full-text (144 KB) | View HTML Full-text | Download XML Full-text
Pharmaceutics 2011, 3(1), 12-33; doi:10.3390/pharmaceutics3010012
Received: 7 December 2010; Accepted: 27 December 2010 / Published: 4 January 2011| Download PDF Full-text (438 KB) | View HTML Full-text | Download XML Full-text
Pharmaceutics 2010, 2(4), 389-418; doi:10.3390/pharmaceutics2040389
Received: 26 October 2010; in revised form: 9 December 2010 / Accepted: 15 December 2010 / Published: 16 December 2010| Download PDF Full-text (284 KB)
Pharmaceutics 2010, 2(4), 364-388; doi:10.3390/pharmaceutics2040364
Received: 15 October 2010; in revised form: 18 November 2010 / Accepted: 24 November 2010 / Published: 29 November 2010| Download PDF Full-text (160 KB)
Article: Timing and Duration of Drug Exposure Affects Outcomes of a Drug-Nutrient Interaction During Ontogeny
Pharmaceutics 2010, 2(4), 321-338; doi:10.3390/pharmaceutics2040321
Received: 9 September 2010; in revised form: 5 October 2010 / Accepted: 12 October 2010 / Published: 14 October 2010| Download PDF Full-text (607 KB)
Review: Tacrolimus Pharmacokinetic and Pharmacogenomic Differences between Adults and Pediatric Solid Organ Transplant Recipients
Pharmaceutics 2010, 2(3), 291-299; doi:10.3390/pharmaceutics2030291
Received: 5 August 2010; in revised form: 23 August 2010 / Accepted: 30 August 2010 / Published: 9 September 2010| Download PDF Full-text (60 KB)
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Last update: 4 March 2014