Pediatric Dosing and Body Size in Biotherapeutics
AbstractAlthough pediatric doses for biotherapeutics are often based on patients' body weight (mg/kg) or body surface area (mg/m2), linear body size dose adjustment is highly empirical. Growth and maturity are also important factors that affect the absorption, distribution, metabolism and excretion (ADME) of biologics in pediatrics. The complexity of the factors involved in pediatric pharmacokinetics lends to the reconsideration of body size based dose adjustment. A proper dosing adjustment for pediatrics should also provide less intersubject variability in the pharmacokinetics and/or pharmacodynamics of the product compared with no dose adjustment. Biological proteins and peptides generally share the same pharmacokinetic principle with small molecules, but the underlying mechanism can be very different. Here, pediatric and adult pharmacokinetic parameters are compared and summarized for selected biotherapeutics. The effect of body size on the pediatric pharmacokinetics for these biological products is discussed in the current review.
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Shi, R.; Derendorf, H. Pediatric Dosing and Body Size in Biotherapeutics. Pharmaceutics 2010, 2, 389-418.
Shi R, Derendorf H. Pediatric Dosing and Body Size in Biotherapeutics. Pharmaceutics. 2010; 2(4):389-418.Chicago/Turabian Style
Shi, Rong; Derendorf, Hartmut. 2010. "Pediatric Dosing and Body Size in Biotherapeutics." Pharmaceutics 2, no. 4: 389-418.