Special Issue "Oral and Buccal Drug Delivery"

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A special issue of Pharmaceutics (ISSN 1999-4923).

Deadline for manuscript submissions: closed (31 January 2012)

Special Issue Editor

Guest Editor
Prof. Claudia S. Leopold

Institute of Pharmacy (Director), Institute of Technical and Macromolecular Chemistry, University of Hamburg, Bundesstr. 45, D-20146 Hamburg, Germany
E-Mail
Fax: +49 40 42838 6519
Interests: tailor-made drug release; colon-speficic drug delivery; ionic interactions; coating stability; shellac; mini tablets; polymorphs; tablet manufacture

Keywords

  • buccal mucosa
  • physiology of the GI tract
  • bioavailability
  • dosage forms for oral/buccal delivery

Published Papers (2 papers)

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Research

Open AccessArticle Application and Characterization of Gum from Bombax buonopozense Calyxes as an Excipient in Tablet Formulation
Pharmaceutics 2012, 4(3), 354-365; doi:10.3390/pharmaceutics4030354
Received: 23 April 2012 / Revised: 19 July 2012 / Accepted: 26 July 2012 / Published: 3 August 2012
Cited by 4 | PDF Full-text (236 KB) | HTML Full-text | XML Full-text
Abstract
This study was undertaken to explore gum from Bombax buonopozense calyxes as a binding agent in formulation of immediate release dosage forms using wet granulation method. The granules were characterized to assess the flow and compression properties and when compressed, non-compendial and compendial
[...] Read more.
This study was undertaken to explore gum from Bombax buonopozense calyxes as a binding agent in formulation of immediate release dosage forms using wet granulation method. The granules were characterized to assess the flow and compression properties and when compressed, non-compendial and compendial tests were undertaken to assess the tablet properties for tablets prepared with bombax gum in comparison with those prepared with tragacanth and acacia gums. Granules prepared with bombax exhibited good flow and compressible properties with angle of repose 28.60°, Carr’s compressibility of 21.30% and Hausner’s quotient of 1.27. The tablets were hard, but did not disintegrate after one hour. Furthermore, only 52.5% of paracetamol was released after one hour. The drug release profile followed zero order kinetics. Tablets prepared with bombax gum have the potential to deliver drugs in a controlled manner over a prolonged period at a constant rate. Full article
(This article belongs to the Special Issue Oral and Buccal Drug Delivery)
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Open AccessArticle Expression Profile of Drug and Nutrient Absorption Related Genes in Madin-Darby Canine Kidney (MDCK) Cells Grown under Differentiation Conditions
Pharmaceutics 2012, 4(2), 314-333; doi:10.3390/pharmaceutics4020314
Received: 7 April 2012 / Revised: 15 May 2012 / Accepted: 6 June 2012 / Published: 18 June 2012
Cited by 5 | PDF Full-text (328 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
The expression levels of genes involved in drug and nutrient absorption were evaluated in the Madin-Darby Canine Kidney (MDCK) in vitro drug absorption model. MDCK cells were grown on plastic surfaces (for 3 days) or on Transwell® membranes (for 3, 5, 7,
[...] Read more.
The expression levels of genes involved in drug and nutrient absorption were evaluated in the Madin-Darby Canine Kidney (MDCK) in vitro drug absorption model. MDCK cells were grown on plastic surfaces (for 3 days) or on Transwell® membranes (for 3, 5, 7, and 9 days). The expression profile of genes including ABC transporters, SLC transporters, and cytochrome P450 (CYP) enzymes was determined using the Affymetrix® Canine GeneChip®. Expression of genes whose probe sets passed a stringent confirmation process was examined. Expression of a few transporter (MDR1, PEPT1 and PEPT2) genes in MDCK cells was confirmed by RT-PCR. The overall gene expression profile was strongly influenced by the type of support the cells were grown on. After 3 days of growth, expression of 28% of the genes was statistically different (1.5-fold cutoff, p < 0.05) between the cells grown on plastic and Transwell® membranes. When cells were differentiated on Transwell® membranes, large changes in gene expression profile were observed during the early stages, which then stabilized after 5–7 days. Only a small number of genes encoding drug absorption related SLC, ABC, and CYP were detected in MDCK cells, and most of them exhibited low hybridization signals. Results from this study provide valuable reference information on endogenous gene expression in MDCK cells that could assist in design of drug-transporter and/or drug-enzyme interaction studies, and help interpret the contributions of various transporters and metabolic enzymes in studies with MDCK cells. Full article
(This article belongs to the Special Issue Oral and Buccal Drug Delivery)
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