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• Ngwuluka, N
• Kyari, J
• Taplong, J
• Uwaezuoke, O
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• Ngwuluka, N
• Kyari, J
• Taplong, J
• Uwaezuoke, O
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• Kyari, J
• Taplong, J
• Uwaezuoke, O

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Pharmaceutics 2012, 4(3), 354-365; doi:10.3390/pharmaceutics4030354

Article

Application and Characterization of Gum from Bombax buonopozense Calyxes as an Excipient in Tablet Formulation

Ndidi C. Ngwuluka ^1,* , Jehu Kyari ¹ , John Taplong ¹  and Onyinye J. Uwaezuoke ²

¹ Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, University of Jos, Jos, 930001, Nigeria ² Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Olabisi Onabanjo University, Ago-Iwoye, 120005, Nigeria

* Author to whom correspondence should be addressed.

Received: 23 April 2012; in revised form: 19 July 2012 / Accepted: 26 July 2012 / Published: 3 August 2012

(This article belongs to the Special Issue Oral and Buccal Drug Delivery)

Download PDF Full-Text [236 KB, uploaded 3 August 2012 15:03 CEST]

Abstract: This study was undertaken to explore gum from Bombax buonopozense calyxes as a binding agent in formulation of immediate release dosage forms using wet granulation method. The granules were characterized to assess the flow and compression properties and when compressed, non-compendial and compendial tests were undertaken to assess the tablet properties for tablets prepared with bombax gum in comparison with those prepared with tragacanth and acacia gums. Granules prepared with bombax exhibited good flow and compressible properties with angle of repose 28.60°, Carr’s compressibility of 21.30% and Hausner’s quotient of 1.27. The tablets were hard, but did not disintegrate after one hour. Furthermore, only 52.5% of paracetamol was released after one hour. The drug release profile followed zero order kinetics. Tablets prepared with bombax gum have the potential to deliver drugs in a controlled manner over a prolonged period at a constant rate.

Keywords: tablets; tablet manufacture; natural gums; Bombax buonopozense; drug delivery; zero order; controlled release; dosage forms; oral delivery

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