Special Issue "Personalized Medicine"
A special issue of Pharmaceuticals (ISSN 1424-8247).
Deadline for manuscript submissions: closed (31 December 2009)
Prof. Dr. Munir Pirmohamed
NHS Chair of Pharmacogenetics, MRC Centre for Drug Safety Sciences,Department of Pharmacology, The University of Liverpool, Ashton Street, Liverpool, L69 3GE, UK
Phone: +44 151 794 5549
Fax: +44 151 794 5540
Interests: pharmacogenomics; stratified medicines; drug safety; clinical pharmacology; alcohol dependency; alcoholic liver disease
Dr. Graeme J. Sills
Division of Neurological Science, University of Liverpool, Clinical Sciences Centre for Research & Education, University Hospital Aintree, Lower Lane, Liverpool L9 7AL, UK
Phone: +44 151 529 5469
Fax: +44 151 529 5465
Interests: pharmacogenomics; metabonomics; epilepsy; antiepileptic drugs; mechanisms of action; drug metabolism; drug resistance
Inter-individual variation in drug response is a major hurdle to successful disease management. Some patients will respond well to the introduction of a new medication, others will achieve little or no benefit, some will get worse, many will not tolerate the new drug and an unfortunate few may experience a severe adverse reaction. This uncertainty about the outcome of treatment is a reflection of the empiricism which remains in modern medicine and which has significant social and economic consequences. The concept of personalized medicine is one in which biological information about an individual is used to optimise the diagnosis and management of their disease. It holds promise for the rational use of therapy and the avoidance of poor and potentially life-threatening outcomes. After many years of wishful predictions, we now stand on the cusp of an era of personalized medicine, with applications already emerging in several areas of clinical care and others expected to bear fruit in due course. This is in part due to the success of the Human Genome Project, an improved understanding of human biology, and the widening availability of technologies to support systems biology research. This special issue of Pharmaceuticals will highlight ongoing investigations and recent developments in the pursuit of personalized medicine in several key therapeutic arenas, with particular emphasis on genetic contributors to variation in drug responsiveness.
Graeme J. Sills, Ph. D.
Prof. Dr. Munir Pirmohamed
- personalized medicine
- combined diagnostics and therapeutics
- systems biology
- individualized treatment
Article: Implications of Inter-Individual Differences in Clopidogrel Metabolism, with Focus on Pharmacogenetics
Pharmaceuticals 2010, 3(4), 782-794; doi:10.3390/ph3040782
Received: 18 January 2010; in revised form: 9 March 2010 / Accepted: 22 March 2010 / Published: 24 March 2010| Cited by 3 | PDF Full-text (125 KB) | XML Full-text
Pharmaceuticals 2010, 3(4), 1122-1138; doi:10.3390/ph3041122
Received: 30 December 2009; in revised form: 12 March 2010 / Accepted: 9 April 2010 / Published: 15 April 2010| Cited by 5 | PDF Full-text (241 KB) | HTML Full-text | XML Full-text
Pharmaceuticals 2010, 3(5), 1637-1651; doi:10.3390/ph3051637
Received: 7 May 2010; Accepted: 24 May 2010 / Published: 25 May 2010| PDF Full-text (127 KB) | HTML Full-text | XML Full-text
Pharmaceuticals 2010, 3(6), 1779-1791; doi:10.3390/ph3061779
Received: 2 March 2010; in revised form: 20 May 2010 / Accepted: 26 May 2010 / Published: 1 June 2010| Cited by 1 | PDF Full-text (265 KB) | HTML Full-text | XML Full-text
Pharmaceuticals 2011, 4(1), 69-90; doi:10.3390/ph4010069
Received: 27 October 2010; in revised form: 7 November 2010 / Accepted: 8 December 2010 / Published: 23 December 2010| Cited by 4 | PDF Full-text (152 KB) | HTML Full-text | XML Full-text
Last update: 4 March 2014