Special Issue "PI3 Kinase Inhibitors"

Guest Editor
Dr. Philip Thompson
Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical, Sciences, Monash University, Parkville 3052, Australia
Website: http://www.pharm.monash.edu.au/
E-Mail: philip.thompson@monash.edu

Dear Colleagues,

Phosphoinositide 3-kinases (PI3K) are important cell signalling enzymes, generating key second messengers that regulate a myriad of cellular functions. In recent years, potential applications for inhibitors have emerged in the treatment of cancer, cardiovascular disease, inflammatory diseases and autoimmune diseases. This special issue hopes to highlight the challenges and lessons learned in going from "hit to lead" and "lead to candidate" when developing targets for PI3K.  Articles that deal with the concepts and results of specific strategic choices in PI3K inhibitor pharmaceutical development are encouraged. These include design approach (eg library screening, structure based design), isoform selectivity, scaffold selection, ADME properties or in vitro/in vivo models. In this issue, I hope novel contributions can be made to the medicinal chemistry knowledge base with original papers or critical reviews.

Dr. Philip Thompson
Guest Editor

Submission

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• PI3 kinase
• phosphatidylinositol
• cell signaling
• cancer therapeutics
• lipid kinase
• inflammation
• immune disease
• thrombosis

Type of Paper: Review
Title: Targeting the PI3 Kinase Signaling in Virus-Associated Cancer
Authors: Mariko Tomita and Shuji Tomita
Affiliation: Department Pathology and Oncology, Graduate School of Medical Science, University of the Ryukyus, Japan;
E-Mail: mtomita@med.u-ryukyu.ac.jp (M.T.)
Abstract: The Phosphoinositide 3-kinases (PI3K) are a family of lipid kinases, that integrate extracellular signal proteins such as growth factors and nutrients, promote cell growth and survival. This signaling pathway is often activated in a variety of human cancers. Thus, PI3K signaling pathway seems to be a good target of cancer treatment and inhibitors of this pathway are developing as anti-cancer agents. In this review, we summarize roles of PI3K signaling in cancers which are caused by human viruses, such as human papilloma virus, hepatitis B virus, hepatitis C virus, Kaposi’s sarcoma-associated herpes virus, Epstein-Barr virus, and human T-cell leukemia virus type. We also discuss the data supporting the use of PI3K inhibitors in these cancers.