Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
9.6
4.3
Journals
ncRNA
Special Issues
Non-Coding RNA and the Immune System
share announcement

Non-Coding RNA and the Immune System

A special issue of Non-Coding RNA (ISSN 2311-553X).

Deadline for manuscript submissions: closed (28 February 2019) | Viewed by 37179

Special Issue Editor

Prof. Dr. Dimitris Lagos

E-Mail Website
Guest Editor
Hull York Medical School and York Biomedical Research Institute, University of York, Wentworth Way, York YO10 5DD, UK
Interests: non-coding RNAs in immunity; immune gene expression; non-coding RNA biogenesis and mechanisms of action

Special Issue Information

Dear Colleagues,

Mammalian genomes are characterised by high prevalence of non-coding RNA (ncRNA) transcripts when compared to other species. It has been proposed that this correlates with the increased complexity of mammals. Undoubtedly, the mammalian immune system is a major contributor to this complexity. This Special Issue will aim to capture and showcase diverse aspects of our current understanding of how ncRNAs underpin complexity of the mammalian immune system.

Manuscripts on the following topics will be welcome:

  • ncRNAs in immune development, differentiation, and lineage plasticity, maintenance, and commitment
  • ncRNAs in infection, immunity, and host–pathogen interactions
  • ncRNAs in chronic inflammation, resolution, and fibrosis
  • Shaping immune transcriptomes through RNA–binding protein/ncRNA interactions
  • Infection exposure as a driver of lncRNA evolution in immune cells

Dr. Dimitris Lagos
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Non-Coding RNA is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microRNAs
  • Long ncRNAs (lncRNAs)
  • circular RNAs (circRNAs)
  • RNA-binding proteins (RBPs)
  • Lineage commitment and plasticity
  • Infection, immunity, and host–pathogen interactions
  • Chronic inflammation, resolution, and fibrosis

Published Papers (6 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

12 pages, 5664 KiB  
Article
Small RNA Species and microRNA Profiles are Altered in Severe Asthma Nanovesicles from Broncho Alveolar Lavage and Associate with Impaired Lung Function and Inflammation
by Ana S. Francisco-Garcia, Eva M. Garrido-Martín, Hitasha Rupani, Laurie C. K. Lau, Rocio T. Martinez-Nunez, Peter H. Howarth and Tilman Sanchez-Elsner
Non-Coding RNA 2019, 5(4), 51; https://doi.org/10.3390/ncrna5040051 - 02 Nov 2019
Cited by 22 | Viewed by 4196
Abstract
MicroRNAs are known to regulate important pathways in asthma pathology including the IL-6 and IFN pathways. MicroRNAs have been found not only within cells but also within extracellular vesicles such as exosomes. In this study, we particularly focused on microRNA cargo of nanovesicles [...] Read more.
MicroRNAs are known to regulate important pathways in asthma pathology including the IL-6 and IFN pathways. MicroRNAs have been found not only within cells but also within extracellular vesicles such as exosomes. In this study, we particularly focused on microRNA cargo of nanovesicles in bronchoalveolar lavage of severe asthmatic patients. We extracted nanovesicle RNA using a serial filtration method. RNA content was analyzed with small RNA sequencing and mapped to pathways affected using WebGestalt 2017 Software. We report that severe asthma patients have deficient loading of microRNAs into their airway luminal nanovesicles and an altered profile of small RNA nanovesicle content (i.e., ribosomal RNA and broken transcripts, etc.). This decrease in microRNA cargo is predicted to increase the expression of genes by promoting inflammation and remodeling. Consistently, a network of microRNAs was associated with decreased FEV1 and increased eosinophilic and neutrophilic inflammation in severe asthma. MicroRNAs in airway nanovesicles may, thus, be valid biomarkers to define abnormal biological disease processes in severe asthma and monitor the impact of interventional therapies. Full article
(This article belongs to the Special Issue Non-Coding RNA and the Immune System)
►▼ Show Figures

Figure 1

Review

Jump to: Research

32 pages, 2962 KiB  
Review
ncRNAs in Type-2 Immunity
by Riccardo Guidi, Christopher J. Wedeles and Mark S. Wilson
Non-Coding RNA 2020, 6(1), 10; https://doi.org/10.3390/ncrna6010010 - 06 Mar 2020
Cited by 11 | Viewed by 5687
Abstract
Immunological diseases, including asthma, autoimmunity and immunodeficiencies, affect a growing percentage of the population with significant unmet medical needs. As we slowly untangle and better appreciate these complex genetic and environment-influenced diseases, new therapeutically targetable pathways are emerging. Non-coding RNA species, which regulate [...] Read more.
Immunological diseases, including asthma, autoimmunity and immunodeficiencies, affect a growing percentage of the population with significant unmet medical needs. As we slowly untangle and better appreciate these complex genetic and environment-influenced diseases, new therapeutically targetable pathways are emerging. Non-coding RNA species, which regulate epigenetic, transcriptional and translational responses are critical regulators of immune cell development, differentiation and effector function, and may represent one such new class of therapeutic targets. In this review we focus on type-2 immune responses, orchestrated by TH2 cell-derived cytokines, IL-4, IL-5 and IL-13, which stimulate a variety of immune and tissue responses- commonly referred to as type-2 immunity. Evolved to protect us from parasitic helminths, type-2 immune responses are observed in individuals with allergic diseases, including Asthma, atopic dermatitis and food allergy. A growing number of studies have identified the involvement of various RNA species, including microRNAs (miRNA) and long non-coding (lncRNA), in type-2 immune responses and in both clinical and pre-clinical disease settings. We highlight these recent findings, identify gaps in our understanding and provide a perspective on how our current understanding can be harnessed for novel treat opportunities to treat type-2 immune-mediated diseases. Full article
(This article belongs to the Special Issue Non-Coding RNA and the Immune System)
►▼ Show Figures

Figure 1

15 pages, 1042 KiB  
Review
Long Non-Coding RNA Function in CD4+ T Cells: What We Know and What Next?
by Katie A. West and Dimitris Lagos
Non-Coding RNA 2019, 5(3), 43; https://doi.org/10.3390/ncrna5030043 - 12 Jul 2019
Cited by 18 | Viewed by 5314
Abstract
The non-coding genome has previously been regarded as “junk” DNA; however, emerging evidence suggests that the non-coding genome accounts for some of the greater biological complexity observed in mammals. Research into long non-coding RNAs (lncRNAs) has gathered speed in recent years, and a [...] Read more.
The non-coding genome has previously been regarded as “junk” DNA; however, emerging evidence suggests that the non-coding genome accounts for some of the greater biological complexity observed in mammals. Research into long non-coding RNAs (lncRNAs) has gathered speed in recent years, and a growing body of evidence has implicated lncRNAs in a vast range of cellular functions including gene regulation, chromosome organisation and splicing. T helper cells offer an ideal platform for the study of lncRNAs given they function as part of a complex cellular network and undergo remarkable and finely regulated gene expression changes upon antigenic stimulation. Using various knock down and RNA interaction studies several lncRNAs have been shown to be crucial for T helper cell differentiation, activation and function. Given that RNA targeting therapeutics are rapidly gaining attention, further understanding the mechanistic role of lncRNAs in a T helper context is an exciting area of research, as it may unearth a wide range of new candidate targets for treatment of CD4+ mediated pathologies. Full article
(This article belongs to the Special Issue Non-Coding RNA and the Immune System)
►▼ Show Figures

Figure 1

24 pages, 1052 KiB  
Review
MicroRNAs in Neuroinflammation: Implications in Disease Pathogenesis, Biomarker Discovery and Therapeutic Applications
by Jessy A. Slota and Stephanie A. Booth
Non-Coding RNA 2019, 5(2), 35; https://doi.org/10.3390/ncrna5020035 - 24 Apr 2019
Cited by 169 | Viewed by 8634
Abstract
The central nervous system can respond to threat via the induction of an inflammatory response. Under normal circumstances this response is tightly controlled, however uncontrolled neuroinflammation is a hallmark of many neurological disorders. MicroRNAs are small non-coding RNA molecules that are important for [...] Read more.
The central nervous system can respond to threat via the induction of an inflammatory response. Under normal circumstances this response is tightly controlled, however uncontrolled neuroinflammation is a hallmark of many neurological disorders. MicroRNAs are small non-coding RNA molecules that are important for regulating many cellular processes. The ability of microRNAs to modulate inflammatory signaling is an area of ongoing research, which has gained much attention in recent years. MicroRNAs may either promote or restrict inflammatory signaling, and either exacerbate or ameliorate the pathological consequences of excessive neuroinflammation. The aim of this review is to summarize the mode of regulation for several important and well-studied microRNAs in the context of neuroinflammation, including miR-155, miR-146a, miR-124, miR-21 and let-7. Furthermore, the pathological consequences of miRNA deregulation during disorders that feature neuroinflammation are discussed, including Multiple Sclerosis, Alzheimer’s disease, Parkinson’s disease, Prion diseases, Japanese encephalitis, Herpes encephalitis, ischemic stroke and traumatic brain injury. There has also been considerable interest in the use of altered microRNA signatures as biomarkers for these disorders. The ability to modulate microRNA expression may even serve as the basis for future therapeutic strategies to help treat pathological neuroinflammation. Full article
(This article belongs to the Special Issue Non-Coding RNA and the Immune System)
►▼ Show Figures

Figure 1

21 pages, 1865 KiB  
Review
Long Non-Coding RNAs and the Innate Immune Response
by Marina R. Hadjicharalambous and Mark A. Lindsay
Non-Coding RNA 2019, 5(2), 34; https://doi.org/10.3390/ncrna5020034 - 19 Apr 2019
Cited by 88 | Viewed by 8156
Abstract
Innate immunity provides the initial defence against infection and it is now clear that long non-coding RNAs (lncRNAs) are important regulators of this response. Following activation of the innate response, we commonly see rapid induction of these lncRNAs and this is often mediated [...] Read more.
Innate immunity provides the initial defence against infection and it is now clear that long non-coding RNAs (lncRNAs) are important regulators of this response. Following activation of the innate response, we commonly see rapid induction of these lncRNAs and this is often mediated via the pro-inflammatory transcription factor, nuclear factor-κB (NF-κB). Knockdown studies have shown that lncRNAs tend to act in trans to regulate the expression of multiple inflammatory mediators and other responses. Mechanistically, many lncRNAs have demonstrated acting through heterogeneous nuclear ribonucleoproteins, complexes that are implicated chromatin re-modelling, transcription process and translation. In addition, these lncRNAs have also been shown to interact with multiple other proteins involved in the regulation of chromatin re-modelling, as well as those proteins involved in intracellular immune signalling, which include NF-κB. In this review, we will describe the evidence that supports this emerging role of lncRNA in the innate immune response. Full article
(This article belongs to the Special Issue Non-Coding RNA and the Immune System)
►▼ Show Figures

Figure 1

22 pages, 1034 KiB  
Review
Crosstalk Between Mammalian Antiviral Pathways
by Samir F. Watson, Lisanne I. Knol, Jeroen Witteveldt and Sara Macias
Non-Coding RNA 2019, 5(1), 29; https://doi.org/10.3390/ncrna5010029 - 22 Mar 2019
Cited by 9 | Viewed by 4557
Abstract
As part of their innate immune response against viral infections, mammals activate the expression of type I interferons to prevent viral replication and dissemination. An antiviral RNAi-based response can be also activated in mammals, suggesting that several mechanisms can co-occur in the same [...] Read more.
As part of their innate immune response against viral infections, mammals activate the expression of type I interferons to prevent viral replication and dissemination. An antiviral RNAi-based response can be also activated in mammals, suggesting that several mechanisms can co-occur in the same cell and that these pathways must interact to enable the best antiviral response. Here, we will review how the classical type I interferon response and the recently described antiviral RNAi pathways interact in mammalian cells. Specifically, we will uncover how the small RNA biogenesis pathway, composed by the nucleases Drosha and Dicer can act as direct antiviral factors, and how the type-I interferon response regulates the function of these. We will also describe how the factors involved in small RNA biogenesis and specific small RNAs impact the activation of the type I interferon response and antiviral activity. With this, we aim to expose the complex and intricate network of interactions between the different antiviral pathways in mammals. Full article
(This article belongs to the Special Issue Non-Coding RNA and the Immune System)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-6
Back to TopTop