Special Issue "Nucleic Acid Derivatives in Emerging Technologies"
Deadline for manuscript submissions: closed (15 December 2008)
Prof. Dr. Per H.J. Carlsen
Department of Chemistry, Norwegian University of Science and Technology, N-7491 Trondheim, Norway
Fax: + 47 73 59 39 85
Interests: organic synthesis; total synthesis; new syntheic methods and reagents; polymer- and surface chemistry; electroactive materials; heterocyclic chemistry; medicinal chemistry; mechanistic organic chemistry; photochemistry
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Author: Takehiko Yokobori, and Masahiko Nishiyama
Affiliation: Department of Molecular Pharmacology and Oncology, Gunma University Graduate School of Medicine,
Abstract: TGF-β superfamily proteins have many important biological function to regulate tissue differentiation, cell proliferation, and migration in both of normal cells and cancer cells. Many researchers have reported TGF-β signaling is associated with cancer progression and therapeutic resistance in several cancers. Similarly, representative TGF-β downstream gene TGFBI was focused as cancer promoter and/or tumor suppressor. In this study we review the basic and clinical research related to the TGF-β and TGFBI in gastrointestinal cancers, especially in gastric cancers and esophageal squamous cell carcinomas.