Special Issue "Metabolomics in Metabolic Engineering"
A special issue of Metabolites (ISSN 2218-1989).
Deadline for manuscript submissions: closed (15 October 2012)
Dr. Edward Eisenstein
Institute for Bioscience and Biotechnology Research (IBBR), Fischell Department of Bioengineering, University of Maryland, 9600 Gudelsky Drive, Room A231, Rockville, MD 20850, USA
Interests: biodesign and biological engineering; plant synthetic biology; protein design and engineering; gene-metabolite relationships in medicinal plants; protein expression and production
Stunning advances in synthetic biology have enabled plants and microorganisms to be engineered for the increased production of a wide variety of useful and important metabolites. These breakthroughs have benefited from computational, experimental and technical developments, especially in the areas of genomics and systems biology, and include transcriptomics and metabolomics, as well as modeling efforts to integrate global data on a cellular level. Improved tools for biodesign are increasing our ability to rapidly identify, manipulate and regulate metabolic pathways. Not only are metabolic engineering efforts enhancing our understanding of how interconnected cellular networks can contribute to and affect metabolism and cellular control, but they are finding broad application to pharmaceutical development, nutritional enhancement of plants to improve human health, biomanufacturing and biofuel production. Accordingly, a special issue of Metabolites will focus on multidisciplinary aspects to the design and engineering of diverse biosystems for the production of endogenous or novel metabolites, and highlight computational, experimental or technical approaches for metabolic engineering.
Dr. Edward Eisenstein
- metabolic engineering
- systems biology
- secondary metabolites
- natural products
Review: Exometabolomics Approaches in Studying the Application of Lignocellulosic Biomass as Fermentation Feedstock
Metabolites 2013, 3(1), 119-143; doi:10.3390/metabo3010119
Received: 12 October 2012; in revised form: 13 December 2012 / Accepted: 28 January 2013 / Published: 11 February 2013| Cited by 2 | PDF Full-text (604 KB) | HTML Full-text | XML Full-text
Article: Changes in Primary and Secondary Metabolite Levels in Response to Gene Targeting-Mediated Site-Directed Mutagenesis of the Anthranilate Synthase Gene in Rice
Metabolites 2012, 2(4), 1123-1138; doi:10.3390/metabo2041123
Received: 16 October 2012; in revised form: 4 December 2012 / Accepted: 9 December 2012 / Published: 18 December 2012| PDF Full-text (679 KB) | HTML Full-text | XML Full-text | Supplementary Files
Metabolites 2012, 2(4), 1090-1122; doi:10.3390/metabo2041090
Received: 1 November 2012; in revised form: 29 November 2012 / Accepted: 10 December 2012 / Published: 14 December 2012| PDF Full-text (338 KB) | HTML Full-text | XML Full-text
Last update: 27 February 2014