Special Issue "Metabolomics in Complex Diseases of Man: Metabolic Syndrome"

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A special issue of Metabolites (ISSN 2218-1989).

Deadline for manuscript submissions: closed (31 March 2014)

Special Issue Editor

Guest Editor
Dr. Vidya Velagapudi (Website)

Metabolomics Unit, Institute for Molecular Medicine Finland FIMM, P.O Box-20, Helsinki-00014, Finland
Phone: 00358503175087
Interests: metabolomics; lipidomics; mass spectrometry; systems medicine, metabolic syndrome

Special Issue Information

Dear Colleagues,

Metabolomics, a systematic study of comprehensive identification and quantification of all the metabolites, is necessary to study the dynamics of the metabolome in metabolic pathways. Deciphering the role of each metabolite following various stimuli aims to find changes in the metabolic network that are functionally correlated with the physiological and developmental phenotype of a cell, tissue or organism. This provides molecular information that has potential applications in understanding pathogenesis. Metabolomics has been playing an important role in unraveling the pathophysiology and identifying early biomarkers of specific physiological responses of complex human diseases in particular metabolic syndrome.

Therefore, this special issue of “Metabolites” journal, “Metabolomics in complex diseases of man: Metabolic syndrome”, will be dedicated for publishing current advances in biomarker discovery and to understand the underlying molecular mechanisms of complex human diseases especially focusing on metabolic syndrome using metabolomics tools. Thus I invite you all to contribute to this special issue by submitting your original research papers and review articles.

Dr. Vidya Velagapudi
Guest Editor

Submission

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed Open Access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is
500 CHF (Swiss Francs). English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.

Keywords

  • global and quantitative metabolomics
  • lipidomics
  • mass spectrometry (MS), LC-MS and GC-MS
  • NMR
  • obesity, diabetes and cardiovascular diseases
  • systems medicine/biology
  • biomarker discovery
  • personalised medicine

Published Papers (1 paper)

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Research

Open AccessArticle Adiponectin Isoforms Differentially Affect Gene Expression and the Lipidome of Primary Human Hepatocytes
Metabolites 2014, 4(2), 394-407; doi:10.3390/metabo4020394
Received: 11 March 2014 / Revised: 6 May 2014 / Accepted: 16 May 2014 / Published: 23 May 2014
Cited by 3 | PDF Full-text (375 KB) | HTML Full-text | XML Full-text
Abstract
Adiponectin (APN) exerts multiple beneficial effects in obesity and protects from liver injury. Different APN isoforms circulate in serum, and here, the effect of low molecular weight (LMW) and higher molecular weight (HMW) APN on primary human hepatocytes (PHH) has been analyzed. [...] Read more.
Adiponectin (APN) exerts multiple beneficial effects in obesity and protects from liver injury. Different APN isoforms circulate in serum, and here, the effect of low molecular weight (LMW) and higher molecular weight (HMW) APN on primary human hepatocytes (PHH) has been analyzed. APN is not detected in hepatocyte lysates; levels are strongly increased by HMW-APN, but not by LMW-APN, suggesting the distinct uptake/degradation of APN isoforms by PHH. Several genes with a role in fibrosis, glucose and lipid metabolism known to be regulated by HMW-APN are not affected by the LMW-isoform. Follistatin is reduced by HMW-APN and induced by LMW-APN in supernatants of PHH. Fibroblast growth factor 21 is repressed by both isoforms. Cellular triglycerides and cholesterol levels are not reduced by APN. Total phospholipids, including plasmalogens and sphingomyelins, are not changed upon APN incubation, while distinct species are either induced or repressed. Unexpectedly, total ceramide is increased by LMW-APN. Current data show that APN isoforms differentially affect hepatocyte gene expression, but do not grossly alter the hepatocyte lipidome. Full article
(This article belongs to the Special Issue Metabolomics in Complex Diseases of Man: Metabolic Syndrome)

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