Submit to Materials Review for Materials Propose a Special Issue

Journal Browser

► Journal Browser

Bone Graft for Bone Regeneration and Dental Implants

Print Special Issue Flyer
Special Issue Editors
Special Issue Information
Keywords
Published Papers

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (20 February 2023) | Viewed by 13281

Share This Special Issue

Special Issue Editor

Prof. Dr. Young-Kyun Kim

E-Mail Website
Guest Editor

Department of Oral and Maxillofacial Surgery, Section of Dentistry, Seoul National University Bundang Hospital, Seongnam, Korea
Interests: dental implant surgery; regenerative medicine; temporomandibular joint disorder; implant; temporomandibular joint

Special Issue Information

Dear Colleagues,

The Special Issue “Bone Graft for Bone Regeneration and Dental Implants” aims to offer a broad overview of the latest concept of minimally invasive surgery for ideal dental implant placement and bone regeneration in the presence of bone defects. We intend to summarize the most recent procedures that satisfy both patients and clinicians through an implant treatment that minimizes complications.

This Special Issue will present scientific research works, clinical studies, reviews, case series studies, etc., related to minimally invasive bone grafts, regenerative medicine for bone regeneration, and digitally guided implant therapy to place an implant in an ideal position at the same time as a bone graft.

Prof. Dr. Young-Kyun Kim
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

bone regeneration
minimally invasive surgery
digitally guided implant

Published Papers (6 papers)

Download All Papers

Research

Jump to: Review

17 pages, 85469 KiB

Open AccessArticle

Effect of Porcine- and Bovine-Derived Xenografts with Hydroxypropyl Methylcellulose for Bone Formation in Rabbit Calvaria Defects

by Su-Hyun Hwang, Keumok Moon, Wen Du, Won-Tak Cho, Jung-Bo Huh and Eun-Bin Bae

Materials 2023, 16(5), 1850; https://doi.org/10.3390/ma16051850 - 23 Feb 2023

Cited by 2 | Viewed by 1610

Abstract

In this study, hydroxypropyl methylcellulose (HPMC) was mixed with particle-type xenografts, derived from two different species (bovine and porcine), to increase the manipulability of bone grafts and compare the bone regeneration ability. Four circular defects with a diameter of 6 mm were formed on each rabbit calvaria, and the defects were randomly divided into three groups: no treatment (control group), HPMC-mixed bovine xenograft (Bo-Hy group), and HPMC-mixed porcine xenograft (Po-Hy group). At eight weeks, micro-computed tomography (µCT) scanning and histomorphometric analyses were performed to evaluate new bone formation within the defects. The results revealed that the defects treated with the Bo-Hy and the Po-Hy showed higher bone regeneration than the control group (p < 0.05), while there was no significant difference between the two xenograft groups (p > 0.05). Within the limitations of the present study, there was no difference in new bone formation between porcine and bovine xenografts with HPMC, and bone graft material was easily moldable with the desired shape during surgery. Therefore, the moldable porcine-derived xenograft with HPMC used in this study could be a promising substitute for the currently used bone grafts as it exhibits good bone regeneration ability for bony defects. Full article

(This article belongs to the Special Issue Bone Graft for Bone Regeneration and Dental Implants)

► Show Figures

Figure 1

9 pages, 1638 KiB

Open AccessArticle

Radiographic and Histomorphometric Evaluation of Sinus Floor Augmentation Using Biomimetic Octacalcium Phosphate Alloplasts: A Prospective Pilot Study

by Seok-Jun Kim, Joo-Seong Kim, Woong Kim, Suk-Young Kim and Won-Pyo Lee

Materials 2022, 15(12), 4061; https://doi.org/10.3390/ma15124061 - 7 Jun 2022

Cited by 2 | Viewed by 1636

Abstract

This prospective single-arm clinical study aimed to radiographically and histomorphometrically evaluate the efficacy of the lateral approach for sinus floor elevation (LSFE) using biomimetic octacalcium phosphate (OCP) synthetic bone graft (Bontree^®). LSFE using Bontree^® was performed on 10 patients (15 implant placement sites) willing to undergo implant surgery, followed by implant placements after 6 months of the healing period. The vertical bone height (VBH) and Hounsfield unit (HU) values at each implant placement site were evaluated radiographically using cone-beam computed tomography at baseline immediately after surgery (T1) and 6 months after surgery (T2). A histomorphometric evaluation of the bone core biopsy specimen was also performed. The mean VBH and HU changes at all sites included a decrease by 0.91 mm and a statistically significant increase by 431.86, respectively, from T1 to T2. The mean ratio of the newly formed bone (23.34% ± 10.63%) was greater than that of the residual bone graft (19.09% ± 8.74%), indicating that Bontree^® is effective for new bone formation. This pilot study suggests that Bontree^® is a promising bone substitute for LSFE. Full article

(This article belongs to the Special Issue Bone Graft for Bone Regeneration and Dental Implants)

► Show Figures

Figure 1

16 pages, 2988 KiB

Open AccessArticle

The Effect of Low-Processing Temperature on the Physicochemical and Mechanical Properties of Bovine Hydroxyapatite Bone Substitutes

by Dina Abdelmoneim, Gemma Claire Porter, Dawn Elizabeth Coates, Warwick John Duncan, John Neil Waddell, Niels Hammer and Kai Chun Li

Materials 2022, 15(8), 2798; https://doi.org/10.3390/ma15082798 - 11 Apr 2022

Cited by 6 | Viewed by 1863

Abstract

Bovine bone grafts (BBX) require protein removal as part of the manufacturing process to reduce antigenicity and, in consequence, to be safely used in humans. Deproteinisation may have direct effects on the characteristics of the bone material and on in vivo material performance. This research aimed to comprehensively study the physicochemical and mechanical properties of BBX processed at low deproteinisation processing temperatures. Cubes of bovine bone (8 mm³) were treated with temperatures between 100 °C and 220 °C at 30 °C intervals and with pressures ranging from 1.01 to 24.58 Bar. The samples were characterised topographically and mechanically using scanning electron microscopy (SEM), atomic force microscopy (AFM), and uniaxial bending tests. The organic content and the chemical composition were determined using thermogravimetric analysis (TGA) and Fourier-transform infrared spectroscopy (FTIR). X-ray diffraction (XRD) and FTIR were also used to quantitatively determine the specimen crystallinity. Increasing temperature/pressure was associated with decreasing protein levels and compressive strength and increasing surface irregularities and crystallinity. The findings suggest that low-temperature processed bone is likely to exhibit a rapid in vivo degradation rate. The deproteinisation temperature can be adjusted to tailor the graft properties for specific applications. Full article

(This article belongs to the Special Issue Bone Graft for Bone Regeneration and Dental Implants)

► Show Figures

Graphical abstract

22 pages, 6237 KiB

Open AccessArticle

The Effect of Low-Temperature Thermal Processing on Bovine Hydroxyapatite Bone Substitutes, toward Bone Cell Interaction and Differentiation

by Gemma Claire Porter, Dina Abdelmoneim, Kai Chun Li, Warwick John Duncan and Dawn Elizabeth Coates

Materials 2022, 15(7), 2504; https://doi.org/10.3390/ma15072504 - 29 Mar 2022

Cited by 4 | Viewed by 1913

Abstract

Ideal bone grafting scaffolds are osteoinductive, osteoconductive, and encourage osteogenesis through the remodeling processes of bone resorption, new bone formation, and successful integration or replacement; however, achieving this trifecta remains challenging. Production methods of bone grafts, such as thermal processing, can have significant effects on the degree of cell-surface interactions via wide-scale changes in the material properties. Here, we investigated the effects of small incremental changes at low thermal processing temperatures on the degree of osteoclast and osteoblast attachment, proliferation, and differentiation. Bovine bone scaffolds were prepared at 100, 130, 160, 190, and 220 °C and compared with a commercial control, Bio-Oss^®. Osteoclast attachment and activity were significantly higher on lower temperature processed bone and were not present ≥190 °C. The highest osteoblast proliferation and differentiation were obtained from treatments at 130 and 160 °C. Similarly, qRT²-PCR assays highlighted osteoblasts attached to bone processed at 130 and 160 °C as demonstrating the highest osteogenic gene expression. This study demonstrated the significant effects of small-scale processing changes on bone graft materials in vitro, which may translate to a tailored approach of cellular response in vivo. Full article

(This article belongs to the Special Issue Bone Graft for Bone Regeneration and Dental Implants)

► Show Figures

Graphical abstract

12 pages, 5084 KiB

Open AccessArticle

The Effect of Whitlockite as an Osteoconductive Synthetic Bone Substitute Material in Animal Bony Defect Model

by Jeong-Kui Ku, Il-hyung Kim, Jung Hee Shim, Yu ha Kim, Baek Hyun Kim, Young-Kyun Kim and Pil-Young Yun

Materials 2022, 15(5), 1921; https://doi.org/10.3390/ma15051921 - 4 Mar 2022

Cited by 5 | Viewed by 2172

Abstract

This study aimed to evaluate the biomechanical properties in vitro and the bone regeneration of whitlockite (WH) compared with hydroxyapatite (HA) or β-tricalcium phosphate (β-TCP)-based material. We investigated the morphology and phase composition of the bone grafts using a scanning electron microscope and X-ray diffractometer patterns and tested the compressive strength. Four circular defects of 8 mm in diameter were created on the calvaria of twelve rabbits. One defect was left empty, and each of the other defects was filled with WH, HA, and β-TCP. At 4 and 8 weeks, the specimens were harvested to evaluate for the new bone formation and the remaining bone grafts. Regarding the biomechanical properties, the three grafts had a similar micropore size, and WH showed nanopores. The compressive strength of WH was higher than HA and β-TCP without statistical significance. The radiological and histomorphometric analyses demonstrated that the new bone formation was similar among the groups. The remaining bone graft of the WH group was greater than that of the HA and β-TCP groups at 4 weeks (p < 0.05), and the total bone area of the WH, HA, and β-TCP groups was greater than that of the other (p < 0.01). WH has excellent volumetric stability and osteoconductivity compared with HA and β-TCP. Full article

(This article belongs to the Special Issue Bone Graft for Bone Regeneration and Dental Implants)

► Show Figures

Figure 1

Review

Jump to: Research

17 pages, 2278 KiB

Open AccessReview

Allogeneic Dentin Graft: A Review on Its Osteoinductivity and Antigenicity

by In-Woong Um, Jeong-Keun Lee, Jun-Young Kim, Yu-Mi Kim, Neema Bakhshalian, Yeong Kon Jeong and Jeong-Kui Ku

Materials 2021, 14(7), 1713; https://doi.org/10.3390/ma14071713 - 31 Mar 2021

Cited by 12 | Viewed by 2726

Abstract

Studies on allogeneic demineralized dentin matrix (Allo-DDM) implantation in the 1960s and 1970s provided the most reliable preclinical evidence of bone formation and antigenicity in an extraosseous site. Recently, applications of Allo-DDM at skeletal sites were studied, and have provided reliable evidence of bone-forming capacity and negligible antigenicity. However, the osteoinductivity and antigenicity properties of Allo-DDM in extraskeletal sites have not yet been investigated due to the lack of follow-up studies after the initial research. The clinical applications of autogenous DDM (Auto-DDM) have been standardized in some countries. Long-term clinical studies have reported the development of several shapes of Auto-DDM, such as powders, blocks, moldable forms, and composites, with recombinant human bone morphogenetic protein-2. For the development of Allo-DDM as a reliable bone graft substitute next to Auto-DDM, we reviewed preclinical studies on the bone induction capacity of allogeneic dentin at extraskeletal as well as skeletal sites. Electronic databases were screened for this review in January 2020 and searched from 1960 to 2019. This review aims to provide a foundation on the preclinical studies of Allo-DDM, which could enable future researches on its osteogenic capability and antigenicity. In conclusion, Allo-DDM showed great potential for osteoinductivity in extraskeletal sites with low antigenicity, which neither adversely affected osteogenic capability nor provoked immunologic reactions. However, the risk of viral disease transmission should be researched before the clinical application of Allo-DDM. Full article

(This article belongs to the Special Issue Bone Graft for Bone Regeneration and Dental Implants)

► Show Figures