Integrative Structural Biology Approaches to Explore Life at a Molecular Level
A special issue of Life (ISSN 2075-1729). This special issue belongs to the section "Biochemistry, Biophysics and Computational Biology".
Deadline for manuscript submissions: closed (23 June 2021) | Viewed by 840
Special Issue Editors
Interests: protein structural biology; x-ray crystallography; single particle cryoelectron microscopy; drug delivery
Interests: protein chemistry; protein structural biology; enzymology; bacterial infectious diseases; drug discovery; misfolded protein; biophysics
Interests: protein structural biology; x-ray crystallography; single particle cryo-electron microscopy; membrane proteins; protein complexes
Special Issue Information
Our understanding of life at a molecular level derives from experimental and in silico analyses of the systems involved in a specific biological process. The investigation of biomacromolecule structures, such as of proteins and of nucleic acids, helps us to elucidate the chemical basis of their functions or disfunctions, which in turn will provide the guide for their pharmacological modulation or for bioengineering approaches to redirect their activity. However, obtaining structural information at quasi-atomic resolution is not always straightforward, especially when the macromolecular target is endowed with structural flexibility and high level of structural complexity.
In recent years, structural biology has experienced a revolution. The arsenal of low- and high-resolution techniques now available offers the possibility of studying even more complex cellular structures in both physiological and pathological conditions at an unprecedented level of detail. An integrative approach which exploits the combination of multiple and complementary methods, and simultaneously provides information at different scale on the same system, is proving successful to model the structures of biological systems. In this special issue, we will present the current strategies used to study both the structure and the dynamics of proteins and protein complexes which are relevant for biomedical and biotechnological applications.
Dr. Linda Montemiglio
Dr. Mirella Vivoli Vega
Dr. Francesca Vallese
Dr. Stefano Stella
Guest Editors
Manuscript Submission Information
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Keywords
- Structural biology
- structure-function relationship
- protein structure and dynamics
- macromolecular complexes/macromolecular interactions
- rational protein design
- x-ray crystallography
- nuclear magnetic resonance spectroscopy
- cryo-electron microscopy
