Alternative Pharmacological Approaches for Septic Shock Management: Beyond Traditional Amine-Based Therapies

Dear Colleagues,

We are excited to announce the forthcoming Special Issue titled "Alternative Pharmacological Approaches for Septic Shock Management: Beyond Traditional Amine-Based Therapies". This issue aims to shed light on the innovative and emerging strategies in the management of septic shock, moving beyond the conventional reliance on amine-based treatments.

The Special Issue seeks contributions that delve into a variety of pharmacological interventions, each targeting different aspects of septic shock pathophysiology:

1. Vasopressin Use and Vascular Tone: Manuscripts discussing the role of vasopressin in modulating vascular tone and reducing catecholamine requirements are highly encouraged.
2. Beta Blockers in Septic Shock: We invite research on beta blockers like esmolol and landiolol, exploring their potential in reducing adrenergic stress and improving patient outcomes.
3. Levosimendan for Septic Cardiomyopathy: Papers investigating the dual role of levosimendan as a myocardial contractility enhancer and vasodilator are sought after.
4. Endocrine Support with Hydrocortisone and Levothyroxine: We are interested in articles that examine the use of hydrocortisone and levothyroxine in supporting compromised endocrine functions in septic shock.
5. Methylene Blue in Nitric Oxide Modulation: Submissions exploring the role of methylene blue in managing vasoplegia and its impact on nitric oxide synthase are welcome.
6. Angiotensin II as a Novel Vasopressor: We look forward to research on the use of angiotensin II in septic shock, especially its effects on the renin–angiotensin system and blood pressure management.

Our goal is to compile a comprehensive collection of articles that provide a detailed overview of these alternative treatments, discussing their mechanisms, clinical evidence, benefits and limitations. We believe that this Special Issue will be an invaluable resource for clinicians, researchers and students interested in the cutting-edge developments in septic shock management.

We encourage authors to submit their original research articles and reviews. This is an excellent opportunity to contribute to a critical field of medical research and share your insights with a global audience. Together, let us explore the frontiers of septic shock treatment and pave the way for improved patient outcomes.

Dr. Guglielmo Consales
Dr. Iacopo Cappellini
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• decatecholaminisation
• non-amine-based therapy
• beta blockers
• hormone replacement
• levosimendan
• Angiotensin II
• sepsis
• septic shock
• septic cardiomyopathy