Personalized Vaccine
A special issue of Journal of Personalized Medicine (ISSN 2075-4426).
Deadline for manuscript submissions: closed (30 September 2014) | Viewed by 217
Special Issue Editor
Special Issue Information
Dear Colleagues,
Immunotherapy is delivering on its long-standing promise of powerful, curative cancer therapy. However, it is unclear which therapy is most suited for a given patient, limiting personalized therapy approaches. Mutated genes in an individual’s cancer cells (the mutanome) encode unique peptides (mutatopes) that can be targets for T cells. The recent arrival of next-generation DNA/RNA sequencing and bioinformatics approaches allows, for the first time, the rapid and affordable identification of mutatopes in individual patients. Despite excitement about the use of mutatopes in personalized immunotherapy, there is no experience or consensus on the path to their successful clinical application. Major questions remain, such as whether clinical responses to cytokine therapy, T cell transfer, and CTLA-4 or PD-(L)1 checkpoint blockade are primarily mediated by mutatope-specific reactivity, or whether mutatopes can be effectively targeted with vaccines. Other options for the personalization of immunotherapy are also beginning to emerge, such as screening for PD-L1 expression in tumors and/or stroma of patients receiving PD-(L)1 checkpoint blockade therapy. This special issue of the Journal of Personalized Medicine will present original articles, reviews and opinions on these and other aspects of the exciting new field of personalized immunotherapy.
Prof. Dr. Willem W. OverwijkGues Editor
Manuscript Submission Information
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Keywords
- cancer vaccines
- personalized medicine
- t cell epitopes
- next-generation sequencing
- epitope prediction
- checkpoint blockade
- vaccine adjuvants
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