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Special Issues
Glaucoma Management in the Era of Personalized Medicine
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Glaucoma Management in the Era of Personalized Medicine

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Clinical Medicine, Cell, and Organism Physiology".

Deadline for manuscript submissions: 26 September 2024 | Viewed by 624

Special Issue Editor

Dr. Clemens A. Strohmaier

E-Mail Website
Guest Editor
Department of Ophthalmology and Optometry, Johannes Kepler University, Linz, Austria
Interests: aqueous outflow physiology; glaucoma surgery

Special Issue Information

Dear Colleagues,

Glaucoma care has evolved tremendously in recent years. Advances in imaging techniques, a better understanding of aqueous humour dynamics or novel biomarkers are just a few examples. We can now tailor the diagnosis, progression monitoring and the medical and surgical treatment to the individual patient to a much greater extent than we were able to just a few years ago. Therefore, I am delighted to be the Guest Editor of this Special Issue on the topic of glaucoma management in the era of personalized medicine. Renowned experts in the field contribute an up-to-date review of their area of expertise. I am confident that this Special Issue will be of great value to clinicians as well as scientists as a go-to reference for up-to-date personalized glaucoma care.

Dr. Clemens A. Strohmaier
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • glaucoma
  • intraocular pressure
  • OCT imaging
  • biomarkers
  • aqueous humour dynamics
  • genetics
  • minimally invasive glaucoma surgery
  • glaucoma surgery
  • medical glaucoma therapy

Published Papers (1 paper)

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Research

16 pages, 3036 KiB  
Article
Protection against Oxidative Stress by Coenzyme Q10 in a Porcine Retinal Degeneration Model
by Leonie Deppe, Ana M. Mueller-Buehl, Teresa Tsai, Carl Erb, H. Burkhard Dick and Stephanie C. Joachim
J. Pers. Med. 2024, 14(4), 437; https://doi.org/10.3390/jpm14040437 - 22 Apr 2024
Viewed by 480
Abstract
Oxidative stress plays an important role in neurodegenerative diseases, including glaucoma. Therefore, we analyzed if the antioxidant coenzyme Q10 (CoQ10), which is also commercially available, can prevent retinal degeneration induced by hydrogen peroxide (H2O2) in a porcine organ culture [...] Read more.
Oxidative stress plays an important role in neurodegenerative diseases, including glaucoma. Therefore, we analyzed if the antioxidant coenzyme Q10 (CoQ10), which is also commercially available, can prevent retinal degeneration induced by hydrogen peroxide (H2O2) in a porcine organ culture model. Retinal explants were cultivated for eight days, and H2O2 (500 µM, 3 h) induced the oxidative damage. CoQ10 therapy was applied (700 µM, 48 h). Retinal ganglion cells (RGCs) and microglia were examined immunohistologically in all groups (control, H2O2, H2O2 + CoQ10). Cellular, oxidative, and inflammatory genes were quantified via RT-qPCR. Strong RGC loss was observed with H2O2 (p ≤ 0.001). CoQ10 elicited RGC protection compared to the damaged group at a histological (p ≤ 0.001) and mRNA level. We detected more microglia cells with H2O2, but CoQ10 reduced this effect (p = 0.004). Cellular protection genes (NRF2) against oxidative stress were stimulated by CoQ10 (p ≤ 0.001). Furthermore, mitochondrial oxidative stress (SOD2) increased through H2O2 (p = 0.038), and CoQ10 reduced it to control level. Our novel results indicate neuroprotection via CoQ10 in porcine retina organ cultures. In particular, CoQ10 appears to protect RGCs by potentially inhibiting apoptosis-related pathways, activating intracellular protection and reducing mitochondrial stress. Full article
(This article belongs to the Special Issue Glaucoma Management in the Era of Personalized Medicine)
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