Immunomodulating Biomaterials for Cell Regulation in Regenerative Medicine of the Musculoskeletal System
A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Bone Biomaterials".
Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 356
Special Issue Editor
Interests: antimicrobial biomaterials; revision arthroplasty; periprosthetic joint infections
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Currently, with few exceptions, non-absorbable biomaterials are used in the field of musculoskeletal surgery for osteosynthesis, joint or limb replacement. For tendon, ligament, cartilage or meniscus replacement, mainly autologous grafts are used in clinical practice. The former strategies are for the supportive repair of a defect and are generally not regenerative in nature. Autologous, allogeneic or xenogeneic grafts have known disadvantages. The use of alloplastic temporary biomaterials has so far focused on biological functionality and biomechanical function. Many of these biodegradable and possibly bioresorbable materials are far too often certified as having relative biocompatibility based on minimal in vitro and in vivo analyses. In addition to other more classical process technologies, other biofabrication technologies such as extrusion bioprinting are now used to advertise tissue and organ replacement in the field of tissue engineering in human medicine in promising forecasts. So far, however, the great successes in the clinic have failed to materialize. The question arises as to why this is so. There are several good reasons why humans have turned out to be the so-called "crown of creation". The human immune system seems to be the linchpin of all regenerative processes. Therefore, we will only be able to treat fractures, tumors, tendon/ligament injuries, degenerative inflammatory processes, etc. of the musculoskeletal system in a curative and regenerative way if we pay more attention to aspects of the human immune system and especially to immune modulation (e.g., by extracellular vesicles).
If we consider Nature’s evolutionary lead and at the same time its molecular, structural repertoire with the “ideal” functionality developed from it, a symbiosis of more innovative, clearly disruptive technologies such as “true” 4D bioprinting, aspects of synthetic biology, multifunctional biomaterial design excluding animal-based substances, etc. is needed. This is a more promising way to generate customized, immunomodulatory, integrative biomaterials with appropriate vital target functionality.
Dr. Jochen Salber
Guest Editor
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Keywords
- musculoskeletal surgery
- biocompatibility
- tissue engineering
- regenerative processes
- immune modulation
- extracellular vesicles
- disruptive technologies
- 4D bioprinting
- synthetic biology
- multifunctional biomaterials
- target functionality
