The Application of Anti-inflammatory Agents in Prostate Cancer

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Nephrology & Urology".

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 6617

Special Issue Editor


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Guest Editor
Department of Urology, Kindai University Faculty of Medicine, Osakasayama 589-8511, Japan
Interests: prostate cancer; inflammation; immune cells; anti-inflammatory agents; diet; lifestyle

Special Issue Information

Dear Colleagues,

Prostate cancer is the most common cancer in many countries resulting in many deaths. Biopsy specimens or prostatectomy specimens indicate the presence of innate and adoptive immune cells in the microenvironments of prostate cancers and recent studies have revealed that inflammation in the tumor microenvironment plays important roles in tumor progression. Cells that comprise the tumor microenvironment can act as a “friend or foe” with many contributing to local inflammation, thus making them potential targets for anti-cancer therapy. Systemic inflammation caused by diet or obesity also leads to prostate cancer progression. Drugs, such as non-steroidal anti-inflammatory agents and metformin, and diets that suppress the inflammatory responses or modulate immune status could have clinical benefits for prostate cancer patients. This Special Issue of the Journal of Clinical Medicine will cover topics regarding inflammation in prostate cancer, anti-inflammatory agents for the treatment of prostate cancer, chemoprevention of prostate cancer, with modulators of inflammation, and diets associated with promoting or suppressing inflammation in prostate cancer.

Dr. Kazutoshi Fujita
Guest Editor

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Published Papers (1 paper)

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Review

28 pages, 1607 KiB  
Review
Application of Anti-Inflammatory Agents in Prostate Cancer
by Koji Hatano, Kazutoshi Fujita and Norio Nonomura
J. Clin. Med. 2020, 9(8), 2680; https://doi.org/10.3390/jcm9082680 - 18 Aug 2020
Cited by 13 | Viewed by 6138
Abstract
Chronic inflammation is a major cause of human cancers. The environmental factors, such as microbiome, dietary components, and obesity, provoke chronic inflammation in the prostate, which promotes cancer development and progression. Crosstalk between immune cells and cancer cells enhances the secretion of intercellular [...] Read more.
Chronic inflammation is a major cause of human cancers. The environmental factors, such as microbiome, dietary components, and obesity, provoke chronic inflammation in the prostate, which promotes cancer development and progression. Crosstalk between immune cells and cancer cells enhances the secretion of intercellular signaling molecules, such as cytokines and chemokines, thereby orchestrating the generation of inflammatory microenvironment. Tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs) play pivotal roles in inflammation-associated cancer by inhibiting effective anti-tumor immunity. Anti-inflammatory agents, such as aspirin, metformin, and statins, have potential application in chemoprevention of prostate cancer. Furthermore, pro-inflammatory immunity-targeted therapies may provide novel strategies to treat patients with cancer. Thus, anti-inflammatory agents are expected to suppress the “vicious cycle” created by immune and cancer cells and inhibit cancer progression. This review has explored the immune cells that facilitate prostate cancer development and progression, with particular focus on the application of anti-inflammatory agents for both chemoprevention and therapeutic approach in prostate cancer. Full article
(This article belongs to the Special Issue The Application of Anti-inflammatory Agents in Prostate Cancer)
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