Special Issue "Hyponatremia: Advances in Diagnosis and Management"
A special issue of Journal of Clinical Medicine (ISSN 2077-0383).
Deadline for manuscript submissions: closed (31 July 2014)
Prof. Dr. Lewis S. Blevins
California Center for Pituitary Disorders, University of California, San Francisco, 400 Parnassus Ave., A-808, San Francisco, California 94143-0350, USA
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Interests: pituitary tumors; hypopituitarism; acromegaly; prolactinoma; transsphenoidal pituitary surgery
Advances in molecular in cell biology have led to important discoveries leading to new therapies in all fields of medicine. This is particularly true in the story of the syndrome of inappropriate anti-diuresis (SIADH), wherein the cloning of the vasopressin receptor has led to drug development for the treatment of euvolemic and hypervolemic hyponatremia, disorders that have been recognized since the advent of accurate and reliable laboratory determinations of the serum sodium. Evaluation and management of patients with hyponatremia has always been based on clinical judgment and is subject to individual interpretation of findings in the clinical context of presentation and recent treatments. Therapies for hyponatremia, including fluid restriction, saline and lasix, 3% saline, and demeclocycline are less than ideal, poorly understood, and often ineffective. Development of a class of drugs known as the vaptans has revolutionized the treatment of euvolemic and hypervolemic hyponatremia.
This Special Issue focuses on compulsive particles that reflect our understanding of the pathophysiology and treatment of hyponatremia and associated consequences.
Prof. Dr. Lewis S. Blevins
Manuscript Submission Information
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- cerebral salt wasting
- osmotic demyelination
- arginine vasopressin receptor
- arginine vasopressin receptor blockers
- vaptans, tolvaptan