Special Issue "Hyponatremia: Advances in Diagnosis and Management"


A special issue of Journal of Clinical Medicine (ISSN 2077-0383).

Deadline for manuscript submissions: closed (31 July 2014)

Special Issue Editor

Guest Editor
Prof. Dr. Lewis S. Blevins
California Center for Pituitary Disorders, University of California, San Francisco, 400 Parnassus Ave., A-808, San Francisco, California 94143-0350, USA
Website: http://neurosurgery.ucsf.edu/index.php/about_us_faculty_blevins.html
E-Mail: blevinsl@neurosurg.ucsf.edu
Phone: 1-866/559-5543
Fax: 415/353-4970
Interests: pituitary tumors; hypopituitarism; acromegaly; prolactinoma; transsphenoidal pituitary surgery

Special Issue Information

Dear Colleagues,

Advances in molecular in cell biology have led to important discoveries leading to new therapies in all fields of medicine. This is particularly true in the story of the syndrome of inappropriate anti-diuresis (SIADH), wherein the cloning of the vasopressin receptor has led to drug development for the treatment of euvolemic and hypervolemic hyponatremia, disorders that have been recognized since the advent of accurate and reliable laboratory determinations of the serum sodium. Evaluation and management of patients with hyponatremia has always been based on clinical judgment and is subject to individual interpretation of findings in the clinical context of presentation and recent treatments. Therapies for hyponatremia, including fluid restriction, saline and lasix, 3% saline, and demeclocycline are less than ideal, poorly understood, and often ineffective. Development of a class of drugs known as the vaptans has revolutionized the treatment of euvolemic and hypervolemic hyponatremia.

This Special Issue focuses on compulsive particles that reflect our understanding of the pathophysiology and treatment of hyponatremia and associated consequences.

Prof. Dr. Lewis S. Blevins
Guest Editor


Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed Open Access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. For the first couple of issues the Article Processing Charge (APC) will be waived for well-prepared manuscripts. English correction and/or formatting fees of 250 CHF (Swiss Francs) will be charged in certain cases for those articles accepted for publication that require extensive additional formatting and/or English corrections.


  • hyponatremia
  • cerebral salt wasting
  • osmotic demyelination
  • arginine vasopressin receptor
  • arginine vasopressin receptor blockers
  • vaptans, tolvaptan

Published Papers (2 papers)

by , , , , , ,  and
J. Clin. Med. 2014, 3(2), 359-372; doi:10.3390/jcm3020359
Received: 11 February 2014; in revised form: 4 March 2014 / Accepted: 7 March 2014 / Published: 4 April 2014
Show/Hide Abstract | PDF Full-text (345 KB) | HTML Full-text | XML Full-text

by , , ,  and
J. Clin. Med. 2014, 3(3), 944-958; doi:10.3390/jcm3030944
Received: 17 June 2014; in revised form: 7 July 2014 / Accepted: 18 July 2014 / Published: 18 August 2014
Show/Hide Abstract | PDF Full-text (752 KB) | HTML Full-text | XML Full-text

Last update: 17 March 2014

J. Clin. Med. EISSN 2077-0383 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert