Infective Endocarditis

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: closed (31 August 2020) | Viewed by 3159

Special Issue Editor


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Guest Editor
Heart & Vascular Center, Department of Cardiothoracic Surgery, Maastricht University Medical Centre (MUMC+), 6229 HX Maastricht, The Netherlands
Interests: endocarditis; mitral and tricuspid valve disease; coronary artery bypass grafting; dilated cardiomyopathy; heart failure

Special Issue Information

Dear Colleagues,

As many of you already know, the rate of infectious endocarditis (IE) has grown considerably in the last decade. In the United States, it increased from 9.3 per 100,000 population in 1998 to 15 per 100,000 in 2011. Oral, gastrointestinal, and cutaneous bacteria are mainly responsible for IE. Staphylococcus aureus is the leading cause of native and prosthetic valve infection, causing 30–40% of IE. Guidelines for surgical treatment of infective endocarditis suggest a surgical approach in the case of acute complications, such as valve dysfunction resulting in heart failure, which are associated with a higher risk of mortality or major morbidity than if treated with antibiotic therapy alone, or in the case of high-risk for embolization. Timing for surgery remains under debate. Surgical treatment of heart valve and prosthesis infective endocarditis (IE) accounts for 25–50% of cases in active IE and 20–40% in treated IE. The mortality rate is very heterogeneous, ranging from 6 to 36%. With this Special Issue, we hope to encourage submissions that discuss the current state-of-the-art, address ongoing knowledge gaps, and focus on ongoing controversies related to infective endocarditis.

We look forward to receiving your submission.

Dr. Michele Di Mauro
Guest Editor

Manuscript Submission Information

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Keywords

  • infective endocarditis
  • vegetations
  • timing of surgery and infective endocarditis
  • heart valve disease
  • bacteremia
  • valve surgery

Published Papers (1 paper)

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Research

11 pages, 567 KiB  
Article
Clinical Characteristics and Outcome of Patients with Infective Endocarditis Diagnosed in a Department of Internal Medicine
by Louis Kreitmann, David Montaigne, David Launay, Sandrine Morell-Dubois, Hélène Maillard, Marc Lambert, Eric Hachulla and Vincent Sobanski
J. Clin. Med. 2020, 9(3), 864; https://doi.org/10.3390/jcm9030864 - 21 Mar 2020
Cited by 8 | Viewed by 2794
Abstract
Clinical manifestations of infective endocarditis (IE) can be highly non-specific. Our objective was to describe the clinical characteristics of patients initially referred to a department of internal medicine for a diagnostic work-up, and eventually diagnosed with IE. We retrospectively retrieved adult patients admitted [...] Read more.
Clinical manifestations of infective endocarditis (IE) can be highly non-specific. Our objective was to describe the clinical characteristics of patients initially referred to a department of internal medicine for a diagnostic work-up, and eventually diagnosed with IE. We retrospectively retrieved adult patients admitted to the department of internal medicine at Lille University Hospital between 2004 and 2015 who fulfilled Duke Classification criteria for definite IE. Thirty-five patients were included. The most frequently involved bacteria were non-hemolytic streptococci. Most patients presented with various systemic, cardiac, embolic, rheumatic, and immunological findings, with no sign or symptom displaying high sensitivity. The first transthoracic echocardiogram was negative in 42% of patients. Furthermore, definite diagnosis required performing at least 2 transesophageal examinations in 24% of patients. We observed a trend towards decreased survival in the subgroup of patients in whom the delay between onset of symptoms and diagnosis was >30 days. In conclusion, patients who are initially referred to internal medicine for a diagnosis work-up and who are ultimately diagnosed with IE have non-specific symptoms and a high percentage of initial normal echocardiography. Those patients require prolonged echocardiographic monitoring as a prolonged delay in diagnosis is associated with poorer outcomes such as death. Full article
(This article belongs to the Special Issue Infective Endocarditis)
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