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Clinical Innovations in Digestive Disease Diagnosis and Treatment
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Clinical Innovations in Digestive Disease Diagnosis and Treatment

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Gastroenterology & Hepatopancreatobiliary Medicine".

Deadline for manuscript submissions: 20 September 2024 | Viewed by 519

Special Issue Editors

Prof. Dr. Stefano Rausei

E-Mail Website
Guest Editor
General Surgery Unit, Department of Surgery, Cittiglio-Angera Hospital, ASST SetteLaghi, 21100 Varese, Italy
Interests: surgical oncology; gastric cancer; colon cancer; minimally invasive surgery; emergency surgery
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Angelo Benevento

E-Mail Website
Guest Editor
General Surgery Unit, Department of Surgery, Gallarate Hospital, ASST Valle Olona, 21052 Busto Arsizio, Italy
Interests: digestive disease; laparoscopic surgery; surgical oncology; gastric cancer; colon cancer; minimally invasive surgery; emergency surgery

Special Issue Information

Dear Colleagues,

This Special Issue aims to highlight the latest advancements in the diagnosis and treatment of digestive diseases, with a focus on clinical innovations. The overarching goal is to address current challenges in the field and provide a comprehensive overview of the research status. Core problems, such as the need for improved diagnostic methods and innovative therapeutic interventions, will be emphasized. The scope of the Special Issue encompasses a wide range of topics, including novel diagnostic technologies, new therapeutic approaches and advancements for inflammatory bowel disease (IBD), early digestive cancers, emergencies in gastrointestinal surgical oncology, anastomotic leakage after surgery, etc. We encourage contributions such as research articles, case studies, and reviews that explore issues such as precision medicine applications, minimally invasive procedures, and the impact of lifestyle on digestive health.

We invite experts in gastroenterology, clinicians, and researchers to contribute their latest findings and experiences. By mobilizing knowledge within this Special Issue, we aim to foster collaboration, encourage idea exchange, and collectively work toward addressing challenges associated with digestive diseases. Additionally, contributions from the National Congress of the Italian Society of Digestive Disease (SIPAD, https://www.sipad.it/area_02_eventi/nazionale_2024.html) scheduled for next May 30–31 in Varese (Italy) are especially welcome, adding valuable insights to this dynamic and evolving field.

Prof. Dr. Stefano Rausei
Prof. Dr. Angelo Benevento
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gastroenterology
  • digestive diseases
  • gastrointestinal endoscopy
  • upper GI surgery
  • colorectal surgery
  • hepatobiliary surgery
  • anastomotic leakage
  • gastrointestinal surgical oncology
  • inflammatory bowel disease
  • precision medicine in gastroenterology
  • minimally invasive gastrointestinal procedures
  • SIPAD congress contributions

Published Papers (1 paper)

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Research

16 pages, 1496 KiB  
Article
Identifying Novel Subtypes of Functional Gastrointestinal Disorder by Analyzing Nonlinear Structure in Integrative Biopsychosocial Questionnaire Data
by Sa-Yoon Park, Hyojin Bae, Ha-Yeong Jeong, Ju Yup Lee, Young-Kyu Kwon and Chang-Eop Kim
J. Clin. Med. 2024, 13(10), 2821; https://doi.org/10.3390/jcm13102821 - 10 May 2024
Viewed by 243
Abstract
Background/Objectives: Given the limited success in treating functional gastrointestinal disorders (FGIDs) through conventional methods, there is a pressing need for tailored treatments that account for the heterogeneity and biopsychosocial factors associated with FGIDs. Here, we considered the potential of novel subtypes of FGIDs [...] Read more.
Background/Objectives: Given the limited success in treating functional gastrointestinal disorders (FGIDs) through conventional methods, there is a pressing need for tailored treatments that account for the heterogeneity and biopsychosocial factors associated with FGIDs. Here, we considered the potential of novel subtypes of FGIDs based on biopsychosocial information. Methods: We collected data from 198 FGID patients utilizing an integrative approach that included the traditional Korean medicine diagnosis questionnaire for digestive symptoms (KM), as well as the 36-item Short Form Health Survey (SF-36), alongside the conventional Rome-criteria-based Korean Bowel Disease Questionnaire (K-BDQ). Multivariate analyses were conducted to assess whether KM or SF-36 provided additional information beyond the K-BDQ and its statistical relevance to symptom severity. Questions related to symptom severity were selected using an extremely randomized trees (ERT) regressor to develop an integrative questionnaire. For the identification of novel subtypes, Uniform Manifold Approximation and Projection and spectral clustering were used for nonlinear dimensionality reduction and clustering, respectively. The validity of the clusters was assessed using certain metrics, such as trustworthiness, silhouette coefficient, and accordance rate. An ERT classifier was employed to further validate the clustered result. Results: The multivariate analyses revealed that SF-36 and KM supplemented the psychosocial aspects lacking in K-BDQ. Through the application of nonlinear clustering using the integrative questionnaire data, four subtypes of FGID were identified: mild, severe, mind-symptom predominance, and body-symptom predominance. Conclusions: The identification of these subtypes offers a framework for personalized treatment strategies, thus potentially enhancing therapeutic outcomes by tailoring interventions to the unique biopsychosocial profiles of FGID patients. Full article
(This article belongs to the Special Issue Clinical Innovations in Digestive Disease Diagnosis and Treatment)
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