Clinical Applications of Tumor Immunotherapy

Dear Colleagues,

The advent of tumor immunotherapy had a significant impact on the treatment landscape of several hematological and solid tumors. The use of immune checkpoint inhibitors (ICIs) is by far the strategy with the most dramatic impact and widest adoption in tumor immunotherapy. These agents block inhibitory interactions between cancer and immune cells, thus prompting antitumor immunity and averting tumor evasion of the immune response. Adoptive cell therapies, such as chimeric antigen receptor T (CAR-T) cells, have been proven to be effective in some hematologic malignancies, with uncertain results in solid tumors. Several other tumor immunotherapy approaches, e.g., therapeutic vaccines and bispecific T cell engagers (BiTE), among others, are actively investigated, with promising results.

Irrespective of the type considered, tumor immunotherapies yielded unprecedented benefits in hard-to-treat tumors in terms of long-lasting responses and the prolongation of survival outcomes, with a peculiar toxicity profile that can be insidious. Research on tumor immunotherapy is brisk and active, currently focusing on how to increase the proportion of patients that benefit from different immunotherapy approaches and on identifying predictive biomarkers of response; thus, it is critical to understand how available evidence and findings, as well as future perspectives, translate into resources for clinical practice.

Dr. Giuseppe Lamberti
Dr. Elisa Andrini
Guest Editors

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• immunotherapy
• PD-1/PD-L1
• CTLA-4
• novel biomarkers
• personalized oncology
• tumor vaccine
• cell therapy
• adoptive immunotherapy
• T cell engagers