Journal of Clinical Medicine

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Special Issue Editors

Dr. Diego Orsini

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Guest Editor

Clinical Dermatology Unit, San Gallicano Dermatological Institute IRCCS, 00144 Rome, Italy
Interests: psoriasis; psoriatic arthritis; atopic dermatitis; eczema; pityriasis versicolor; venereology

Dr. Alessandra Narcisi

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Guest Editor

1. Dermatology Unit, IRCCS Humanitas Research Hospital, 20089 Rozzano, MI, Italy
2. Department of Biomedical Sciences, Humanitas University, 20072 Pieve Emanuele, MI, Italy
Interests: psoriasis; biologics; atopic dermatitis; inflammatory skin diseases; translational research
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Psoriasis is a common, chronic, inflammatory, immune-mediated skin disease with a high prevalence worldwide. It is a chronic, relapsing–remitting, inflammatory autoimmune disease involving several factors. The complexity of psoriasis is also reflected in the comorbidities that accompany psoriasis, mainly affecting the skin and joints.

Recent therapeutic advances in psoriasis and psoriatic arthritis are compelling. We now have multiple options for treating the patient in front of us, but this also creates the dilemma of making the right treatment choice. This Special Issue aims to accumulate the latest reviews and original articles on psoriasis and psoriatic arthritis, with the aim of exploring the latest developments in all aspects of psoriasis and contributing to decision-making in our daily medical practice.

Dr. Diego Orsini
Dr. Alessandra Narcisi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

psoriasis
psoriatic arthritis
inflammatory skin disease
inflammatory autoimmune disease
immunotherapy
autoimmunity
comorbidities
therapeutic
diagnosis
treatment
management
biologics

Published Papers (2 papers)

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Research

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13 pages, 887 KiB

Open AccessArticle

Platelet Reactivity in the Exacerbation of Psoriasis

by Piotr Adamski, Urszula Adamska, Katarzyna Buszko, Joanna Sikora and Rafał Czajkowski

J. Clin. Med. 2024, 13(4), 965; https://doi.org/10.3390/jcm13040965 - 8 Feb 2024

Viewed by 756

Abstract

Background: Psoriasis is a chronic, inflammatory, immune-mediated disease with a specific cutaneous presentation. Increased platelet aggregation has been observed in patients with extensive psoriatic lesions. The aim of this study was to evaluate the clinical factors affecting platelet reactivity in patients with an exacerbation of psoriasis. Methods: This was a prospective, single-center, observational study, enrolling patients hospitalized for an aggravation of psoriasis. Enrolled patients underwent single platelet function testing with light transmission aggregometry on the first morning of hospitalization. Results: 120 patients were enrolled in the study. Of the compared subgroups, women had higher maximal platelet aggregation (MPA) than men (77% vs. 72%; p = 0.03), and those with BMIs < 25 kg/m² showed higher platelet reactivity compared to subjects with BMIs ≥ 25 kg/m² (75% vs. 73%; p = 0.02). There was a positive correlation between MPA and platelet count (r = 0.27; p < 0.01), as well as C-reactive protein concentration (r = 0.20; p = 0.03), while a negative correlation was observed with total cholesterol (r = −0.24; p = 0.01) and triglycerides (r = −0.30; p < 0.01). A two-step analysis based on multidimensional models with random effects revealed that every increase in the platelet count by 10³/μL led to an increase in MPA by 0.07% (R² = 0.07; p < 0.01), and an increase in triglycerides’ concentration by 1 mg/dL was related to a reduction in MPA by 0.05% (R² = 0.07; p < 0.01). Conclusions: The increased platelet reactivity observed in patients with psoriasis appears to be multifactorial and related to several clinical and laboratory features. Further research is warranted to put these findings into a clinical perspective. Full article

(This article belongs to the Special Issue New Clinical Advances in Psoriasis and Psoriatic Arthritis)

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37 pages, 2040 KiB

Open AccessSystematic Review

An Overview of Growth Factors as the Potential Link between Psoriasis and Metabolic Syndrome

by Mateusz Matwiejuk, Hanna Myśliwiec, Adrian Chabowski and Iwona Flisiak

J. Clin. Med. 2024, 13(1), 109; https://doi.org/10.3390/jcm13010109 - 24 Dec 2023

Cited by 1 | Viewed by 1255

Abstract

Psoriasis is a chronic, complex, and immunologically mediated systemic disease that not only affects the skin, but also the joints and nails. It may coexist with various other disorders, such as depression, psoriatic arthritis, cardiovascular diseases, diabetes mellitus, and metabolic syndrome. In particular, the potential link between psoriasis and metabolic syndrome is an issue worthy of attention. The dysregulation of growth factors could potentially contribute to the disturbances of keratinocyte proliferation, inflammation, and itch severity. However, the pathophysiology of psoriasis and its comorbidities, such as metabolic syndrome, remains incompletely elucidated. Growth factors and their abnormal metabolism may be a potential link connecting these conditions. Overall, the objective of this review is to analyze the role of growth factor disturbances in both psoriasis and metabolic syndrome. Full article

(This article belongs to the Special Issue New Clinical Advances in Psoriasis and Psoriatic Arthritis)

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