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Kidney Transplantation: Current Challenges and Future Perspectives
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Kidney Transplantation: Current Challenges and Future Perspectives

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Nephrology & Urology".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 1424

Special Issue Editors

Dr. Alberto Piana

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Guest Editor
Department of Oncology, Division of Urology, San Luigi Gonzaga Hospital, University of Turin, 10043 Orbassano, Italy
Interests: kidney transplantation; urologic oncology; endourology; urolithiasis; laparoscopic urology; prostate; prostate cancer
Dr. Angelo Territo

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Guest Editor
Unit of Uro-oncology and Kidney Transplant, Department of Urology, Puigvert Foundation, Universitat Autònoma de Barcelona (UAB), 08193 Barcelona, Spain
Interests: kidney transplantation; minimally invasive surgery; laparoscopic surgery; renal

Special Issue Information

Dear Colleagues,

This Special Issue aims to investigate new scenarios and challenges in the field of kidney transplantation.

This Special Issue invites original research articles, review papers, and clinical studies that contribute to enrich our knowledge about kidney transplantation. We encourage submissions focusing on topics such as urologic cancers in transplanted patients, surgical challenges in kidney transplantation, and the use of technology for patient-tailored clinical management.

To ensure the highest-quality publications, we kindly request that authors refrain from submitting mini-reviews and case reports for this Special Issue. Instead, we seek in-depth research articles and comprehensive reviews that present novel findings and insights into kidney transplantation.

By bringing together leading experts and researchers in the field, this Special Issue aims to foster interdisciplinary discussions and promote collaborations to address the pressing issues faced in kidney transplantation. We believe that this collection of articles will serve as a valuable resource for clinicians and researchers involved in improving patient outcomes and advancing the field of kidney transplantation.

Dr. Alberto Piana
Dr. Angelo Territo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • kidney transplantation
  • urologic cancers
  • organ preservation
  • surgical challenges
  • donor selection
  • long-term out-comes
  • complications
  • post-transplant care
  • technology

Published Papers (2 papers)

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Research

14 pages, 261 KiB  
Article
Effect of Different Induction Immunosuppression on the Incidence of Infectious Complications after Kidney Transplantation—Single Center Study
by Matej Vnučák, Karol Graňák, Monika Beliančinová, Patrícia Kleinová, Tímea Blichová, Vladimír Doboš and Ivana Dedinská
J. Clin. Med. 2024, 13(8), 2162; https://doi.org/10.3390/jcm13082162 - 9 Apr 2024
Viewed by 507
Abstract
Background/Objectives: Potent immunosuppression lowers the incidence of acute graft rejection but increases the risk of infections. In order to decrease either infectious complications or acute rejection, it is necessary to identify risk groups of patients profiting from personalized induction immunosuppressive treatment. The aim [...] Read more.
Background/Objectives: Potent immunosuppression lowers the incidence of acute graft rejection but increases the risk of infections. In order to decrease either infectious complications or acute rejection, it is necessary to identify risk groups of patients profiting from personalized induction immunosuppressive treatment. The aim of our analysis was to find whether there were higher incidences of infectious complications after kidney transplantation (KT) in groups with different induction immunosuppressive treatment and also to find independent risk factors for recurrent infections. Materials: We retrospectively evaluated all patients with induction treatment with basiliximab after kidney transplantation from 2014 to 2019 at our center relative to age- and sex-matched controls of patients with thymoglobulin induction immunosuppression. Results: Our study consisted of two groups: basiliximab (39) and thymoglobulin (39). In the thymoglobulin group we observed an increased incidence of recurrent infection in every observed interval; however, acute rejection was seen more often in the basiliximab group. A history of respiratory diseases and thrombocytopenia were identified as independent risk factors for recurrent bacterial infections from the first to sixth month after KT. Decreased eGFR from the first month, infections caused by multi-drug-resistant bacteria, and severe infections (reflected by the need for hospitalization) were identified as independent risk factors for recurrent bacterial infections from the first to the twelfth month after KT. Conclusions: We found that in the group of patients with thymoglobulin induction immunosuppressive treatment, infectious complications occurred significantly more often during the entire monitored period with decreased incidence of acute humoral and cellular rejection occurred more often. Full article
(This article belongs to the Special Issue Kidney Transplantation: Current Challenges and Future Perspectives)
11 pages, 401 KiB  
Article
The Minimisation of Cardiovascular Disease Screening for Kidney Transplant Candidates
by Michael Corr, Amber Orr and Aisling E. Courtney
J. Clin. Med. 2024, 13(4), 953; https://doi.org/10.3390/jcm13040953 - 7 Feb 2024
Viewed by 711
Abstract
Background: There is increasing evidence that cardiac screening prior to kidney transplantation does not improve its outcomes. However, risk aversion to perioperative events means that, in practice, testing remains common, limiting the availability of ‘real-world’ data to support any change. Our objective [...] Read more.
Background: There is increasing evidence that cardiac screening prior to kidney transplantation does not improve its outcomes. However, risk aversion to perioperative events means that, in practice, testing remains common, limiting the availability of ‘real-world’ data to support any change. Our objective was to assess perioperative and 1-year post-transplant cardiovascular events in a kidney transplant candidate cohort who received minimal cardiovascular screening. Methods: The retrospective cohort study included all adult kidney-only transplant recipients in a single UK region between January 2015 and December 2021. Kidney transplant recipients asymptomatic of cardiac disease, even those with established risk factors, did not receive cardiac stress testing. The perioperative and 1-year post-transplant cardiovascular event incidences were examined. Logistic regression was used to identify variables of statistical significance that predicted cardiovascular or cerebrovascular events. Results: A total of 895 recipients fulfilled the inclusion criteria. Prior to transplantation, 209 (23%) recipients had an established cardiac diagnosis, and 193 (22%) individuals had a diagnosis of diabetes. A total of 18 (2%) patients had a perioperative event, and there was a 5.7% incidence of cardiovascular events 1 year post-transplantation. The cardiovascular mortality rate was 0.0% perioperatively, 0.2% at 3 months post-transplant, and 0.2% at 1 year post-transplant. Conclusions: This study demonstrates comparable rates of cardiovascular events despite reduced screening in asymptomatic recipients. It included higher risk individuals who may, on the basis of screening results, have been excluded from transplantation in other programmes. It provides further evidence that extensive cardiac screening prior to kidney transplantation is unlikely to be offset by reduced rates of cardiovascular events. Full article
(This article belongs to the Special Issue Kidney Transplantation: Current Challenges and Future Perspectives)
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