Journal of Clinical Medicine

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Special Issue Editors

Dr. Marco Simonini

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Guest Editor

Chair of Nephrology, Vita-Salute University San Raffaele and Genomics of Renal Diseases and Hypertension Unit, IRCCS San Raffaele Scientific Institute, 60, 20132 Milan, Italy
Interests: AKI; S-AKI; CRRT; CKD and dialysis; hypertension; biomarkers

Dr. Chiara Lanzani

E-Mail Website
Guest Editor

Chair of Nephrology, Vita-Salute University San Raffaele and Genomics of Renal Diseases and Hypertension Unit, IRCCS San Raffaele Scientific Institute, 60, 20132 Milan, Italy
Interests: AKI; hypertension; genetics of complex disease; dialysis; glomerular disease; RAAS system

Special Issue Information

Dear Colleagues,

Acute kidney injury (AKI) is a common complication of sepsis, which is associated with higher risks of adverse outcomes. Despite identification of several cellular mechanisms thought to underlie the development of organ damage in septic patients, the pathophysiology of AKI is still poorly understood. This is the main reason whereby the mortality of AKI in septic critically ill patients remains high despite our increasing ability to support vital organs. Indeed, sepsis-associated acute kidney injury (S-AKI) significantly worsens the prognosis of patients and subjects with S-AKI are at increased risk of developing chronic kidney disease (CKD).

The purpose of this Special Issue is to publish high-quality research papers as well as review articles addressing recent advances in S-AKI. Original, high-quality contributions that are not yet published or that are not currently under review by other journals or peer-reviewed conferences are welcome.

Potential topics include, but are not limited to:

New insights on sepsis-associated AKI development
Identification of new biomarkers S-AKI
Identification of new potential therapeutic targets
Early identification of organ dysfunction in septic condition
Stratification of high-risk patients
Prognostic value in critical condition S-AKI
CRRT for sepsis-induced acute kidney injury
Extracorporeal blood purification therapies
Follow-up after acute illness
Kidney function recovery after a septic event

Dr. Marco Simonini
Dr. Chiara Lanzani
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

AKI
sepsis
septic shock
S-AKI
biomarker
AKI to CKD transition
CRRT
blood purification
SOFA system

Published Papers (2 papers)

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Research

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12 pages, 2296 KiB

Open AccessArticle

A National Case-Crossover Study on the Risk of Kidney Injury Requiring Dialysis after Sepsis

by Chung-Shun Wong, Tzu-Ting Chen, Andrei R. Akhmetzhanov, Ping-Jen Hu, Mai-Szu Wu and Mei-Yi Wu

J. Clin. Med. 2023, 12(15), 4950; https://doi.org/10.3390/jcm12154950 - 27 Jul 2023

Viewed by 732

Abstract

Background: Patients with sepsis-associated acute kidney injury (AKI) are at risk of kidney damage, potentially necessitating acute temporary or chronic dialysis. Our study aims to estimate the odds ratio (OR) of preceding sepsis among patients requiring their first dialysis. Methods: A nationwide population-based case-only study was conducted using claims records from the National Health insurance database of Taiwan. All patients over 20 years of age who underwent their first dialysis between 2004 and 2016 were included in the study. The six months prior to their first dialysis served as a self-control period. Results: The study included 147,201 patients who required acute temporary and 75,031 patients who required chronic dialysis. The odds ratios for patients needing acute temporary dialysis after 1, 2, 3, and 4 weeks of exposure periods were 15.8, 10.7, 9.2, and 8.4, respectively. The ORs for patients requiring chronic dialysis were 7.0, 4.1, 4.2, and 3.7, respectively. Conclusions: Our findings indicate that sepsis was substantially associated with an increased risk of renal failure. The risk was highest during the first week following sepsis for both acute temporary and chronic dialysis cases. Full article

(This article belongs to the Special Issue Sepsis-Associated Acute Kidney Injury: A Problem Deserving of New Solutions)

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Other

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19 pages, 1452 KiB

Open AccessSystematic Review

Role of the Renin Angiotensin Aldosterone System in the Pathogenesis of Sepsis-Induced Acute Kidney Injury: A Systematic Review

by Sedra Tibi, Garbel Zeynalvand and Hina Mohsin

J. Clin. Med. 2023, 12(14), 4566; https://doi.org/10.3390/jcm12144566 - 8 Jul 2023

Cited by 3 | Viewed by 3594

Abstract

Background: Sepsis is a life-threatening condition responsible for up to 20% of all global deaths. Kidneys are among the most common organs implicated, yet the pathogenesis of sepsis-induced acute kidney injury (S-AKI) is not completely understood, resulting in the treatment being nonspecific and responsive. In situations of stress, the renin angiotensin aldosterone system (RAAS) may play a role. This systematic review focuses on analyzing the impact of the RAAS on the development of S-AKI and discussing the use of RAAS antagonists as an emerging therapeutic option to minimize complications of sepsis. Methods: Studies were identified using electronic databases (Medline via PubMed, Google Scholar) published within the past decade, comprised from 2014 to 2023. The search strategy was conducted using the following keywords: sepsis, S-AKI, RAAS, Angiotensin II, and RAAS inhibitors. Studies on human and animal subjects were included if relevant to the keywords. Results: Our search identified 22 eligible references pertaining to the inclusion criteria. Treatment of sepsis with RAAS inhibitor medications is observed to decrease rates of S-AKI, reduce the severity of S-AKI, and offer an improved prognosis for septic patients. Conclusion: The use of RAAS antagonists as a treatment after the onset of sepsis has promising findings, with evidence of decreased renal tissue damage and rates of S-AKI and improved survival outcomes. Registration: INPLASY202360098. Full article

(This article belongs to the Special Issue Sepsis-Associated Acute Kidney Injury: A Problem Deserving of New Solutions)

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