Valvular Heart Disease: Challenges and New Opportunities

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiology".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 1354

Special Issue Editor


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Guest Editor
1. Department of Cardiology, San Giovanni Battista Hospital, Foligno, Italy
2. Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands
Interests: aortic valve; tricuspid regurgitation; mitral regurgitation; valvular heart disease; echocardiography; cardiac magnetic resonance; cardiac computed tomography; multimodality imaging; cardiovascular imaging; cardiovascular disease; coronary artery disease; atherosclerosis; heart failure; myocardial infarction

Special Issue Information

Dear Colleagues,

We invite you to participate in this Special Issue of JCM, entitled “Valvular Heart Disease: Challenges and New Opportunities”. As is well-known, with the aging of the population, the prevalence of acquired valvular heart disease (VHD) is rapidly growing and, today, it is among the most common causes of cardiovascular morbidity and mortality. Furthermore, VHD may significantly affect the patients’ well-being and reduce their quality of life.

Although several new therapeutical options have been proposed in recent years, there are still important gaps in the understanding of the imaging and clinical parameters that should be considered for optimal patient selection, timing for referral and long-term outcome prediction. With this Special Issue, we seek to provide an overview of the latest advances in the imaging and therapeutic options for patients with VHD with a particular focus on the role of multimodality imaging assessment (including 2D and 3D echocardiography, speckle tracking echocardiography, non-invasive myocardial work assessment, cardiac computed tomography, cardiac magnetic resonance, nuclear imaging and fusion imaging) and imaging markers for risk stratification and outcome prediction in VHD patients. 

We look forward to receiving your submissions to this Special Issue.

Dr. Federico Fortuni
Guest Editor

Manuscript Submission Information

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Keywords

  • aortic valve
  • aortic stenosis
  • aortic regurgitation
  • tricuspid regurgitation
  • mitral regurgitation
  • mitral stenosis
  • valvular heart disease
  • echocardiography
  • cardiac magnetic resonance
  • cardiac computed tomography
  • multimodality imaging
  • cardiovascular imaging

Published Papers (1 paper)

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Research

14 pages, 1510 KiB  
Article
Low Bone Mineral Density on Computed Tomography: Association with Poor Survival after Transcatheter Aortic Valve Replacement
by Caglayan Demirel, Kseniya Halavina, Kevin Hamzaraj, Johanna Klement, Manar El-Shaer, Rayyan Hemetsberger, Max Paul Winter, Sophia Koschatko, Charlotte Jantsch, Martin Andreas, Christian Loewe, Andreas Kammerlander, Christian Hengstenberg and Philipp E. Bartko
J. Clin. Med. 2024, 13(9), 2698; https://doi.org/10.3390/jcm13092698 - 3 May 2024
Viewed by 977
Abstract
Background: Transcatheter aortic valve replacement (TAVR) has evolved as first-line therapy for severe aortic valve stenosis (AS), with pre-procedural computed tomography (CT) providing critical anatomical information. While primarily used for anatomical planning, TAVR-CT also offers an opportunity to assess low bone mineral density [...] Read more.
Background: Transcatheter aortic valve replacement (TAVR) has evolved as first-line therapy for severe aortic valve stenosis (AS), with pre-procedural computed tomography (CT) providing critical anatomical information. While primarily used for anatomical planning, TAVR-CT also offers an opportunity to assess low bone mineral density (BMD), a known indicator of frailty. Despite this, the prognostic role of BMD in TAVR patients remains unknown. This study aimed to evaluate BMD on routine TAVR-CT and its impact on long-term survival. Methods: In this retrospective study, 770 consecutive TAVR patients (mean age 80.7 ± 6.7 years, 54.0% males) between November 2015 and March 2022 were included. BMD was measured from a single axial image at the thoracic vertebral level on unenhanced CT scans. Cox regression models assessed the impact of BMD on mortality, and Restricted Cubic Spline models identified potential mortality thresholds. Results: The mean BMD value, as measured on non-contrast CT, was 147.5 ± 5.4 Hounsfield units, demonstrating a noteworthy association with mortality (adjusted hazard ratio per 100 HU decrease: 1.27 [95%CI: 1.01–1.59], p = 0.041). Restricted cubic spline analysis indicated that BMD below 200 HU was linked to a substantial increase in mortality risk. Upon crude Cox regression analysis, every 100 HU decrease was associated with a 32% increase in risk for death (HR 1.32 [95%CI: 1.068–1.65)], p = 0.010). Conclusions: In conclusion, low BMD on TAVR-CT is independently associated with reduced survival, suggesting its potential as a tool for comprehensive frailty assessment and improved risk prediction in TAVR patients. Full article
(This article belongs to the Special Issue Valvular Heart Disease: Challenges and New Opportunities)
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