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JCM
Special Issues
Squamous Cell Carcinoma: Current Status and Future Challenges
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Squamous Cell Carcinoma: Current Status and Future Challenges

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dermatology".

Deadline for manuscript submissions: 30 June 2024 | Viewed by 858

Special Issue Editor

Prof. Dr. Emilio Trignano

E-Mail Website
Guest Editor
1. Plastic Surgery Unit, University Hospital Trust of Sassari, 07100 Sassari, Italy
2. Department of Medicine, Surgery and Pharmacy, University of Sassari, 07100 Sassari, Italy
Interests: skin tumors; squamous cell carcinoma; basal cell carcinoma; spinal cell carcinoma; melanoma

Special Issue Information

Dear Colleagues,

Squamous cell carcinoma (SCC) is a prevalent malignancy with rising incidence and elevated morbimortality due to its metastatic potential. The management of advanced or recurrent cases demands a multidisciplinary approach that integrates surgery, radiotherapy and immunotherapy, thus improving therapeutic outcomes, especially in high-risk patients. Understanding of the genetic profile can provide additional prognostic information for the development of new therapeutic strategies and surveillance protocols.

In this Special Issue, we aim to address the current state of the art in the management of SCCs, alongside highlighting major advances in their staging, prognostication, and treatment.

Prof. Dr. Emilio Trignano
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • squamous cell carcinoma
  • genetic profile
  • immunotherapy
  • metastatic SCC
  • recurrent SCC
  • multidisciplinary
  • adjuvant
  • surgical treatment

Published Papers (1 paper)

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Research

12 pages, 4020 KiB  
Article
Salvage Strategies for Local Recurrences of Squamous Cell Carcinoma of the Nasal Vestibule: A Single-Center Experience of 22 Years
by Corrado Rubino, Emilio Trignano, Francesco Bussu, Pietro Luciano Serra, Manuela Rodio, Matilde Tettamanzi and Silvia Rampazzo
J. Clin. Med. 2024, 13(2), 541; https://doi.org/10.3390/jcm13020541 - 18 Jan 2024
Viewed by 690
Abstract
Squamous cell carcinomas of the nasal vestibule are an extremely rare neoplastic disease. Although brachytherapy is gaining popularity for primary treatment, surgery remains the best option in case of recurrences. The aim of this paper is to outline our treatment experience of local [...] Read more.
Squamous cell carcinomas of the nasal vestibule are an extremely rare neoplastic disease. Although brachytherapy is gaining popularity for primary treatment, surgery remains the best option in case of recurrences. The aim of this paper is to outline our treatment experience of local recurrence of SCCNVs over the past 22 years. We retrospectively reviewed the clinical data of the patients who underwent surgical treatment for local recurrence of SCCNV: data regarding age, sex, primary tumor treatment, recurrence location and time of appearance, surgical resection, type of reconstruction, postoperative complication, surgical revision, and re-recurrence rate were analyzed. Twenty patients were included in the study. The median period for recurrence appearance was 17 months, and the prevalent location of recurrence was the nasal alae. Prevalent reconstructive procedures were the nasolabial flap and paramedian forehead flap. No postoperative complications were observed, and one case of re-recurrence was detected at 12-months of follow-up. Based on our experience, salvage surgical procedures for SCCNV recurrences must be individualized and carefully planned, taking into account the peculiar pattern of tumor spread and the presence of scar and heavily radiotherapy damaged tissue from previous treatment; delayed reconstruction should be considered for all the cases with skeletal involvement. Full article
(This article belongs to the Special Issue Squamous Cell Carcinoma: Current Status and Future Challenges)
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